It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. What does chloroquine do in transfection What does plaquenil do to your eyesight Plaquenil needs time to build up in your system. As with any AI, you can a remission or a change in the symptoms you feel from day to day, week to week, etc. I know for me I have what I call "good days" and I have "bad days". Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. I take Nsaids for pain to get me through a work day when I am having a tough time. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Plaquenil time to work Lupus Medicines Hydroxychloroquine - Brigham and Women's., Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Chloroquine storage Someone else told me that plaquenil could take up to a year to work. Others have told me that it only took a few months for them to feel the effects. Everyone is different. I can tell you that plaquenil is the safest of all of the DMARDs. If you're going to stay on a DMARD for a long time, plaquenil is the one to be on. Best of luck on the. Plaquenil -. Plaquenil for fatigue and pain DailyStrength. How does Plaquenil work?. How long does it take for plaquenil to work? I just started about 6 weeks ago, the rheum said it can take up to a year. Let me know how you are doing on it! Last week my doc added plaquenil to the mix. I have a pharmacist friend that says it can take up to a year to work, but once its kicks in it can be really good. I suggest you ask your rhuemie for additional help in the meantime. I have had RA going on 12 years, and originally way back when I ws given plaquenil alone and it did nothing. My doctor put me on prednisone at the same time with plaquenil and it was within a month I started noticing it helping. He said it would help in the meantime it takes the plaquenil to get absorbed in my body. Hopefully I'll be done with the prednisone in a couple weeks as it makes me bloated. That was my rheumatologist and he has been the best.