In fact, most people with lupus have fatigue at some point in their illness. “When lupus hit, it was like running into a wall at 80 mph,” says Ann S. Why use plaquenil for scleroderma What drug is similiar to plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. “I had been very active my whole life, and the fatigue just knocked me flat. Utterback, Ph D, a broadcast voice specialist in Virginia who was diagnosed with lupus in 2006. Does plaquenil help with fatigue Common and Rare Side Effects for Plaquenil Oral, Plaquenil for fatigue and pain DailyStrength Eye exam for plaquenilHydroxychloroquine alopecia Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. While there is good clinical evidence demonstrating. Ask the Expert Plaquenil and Sjögren’s. Taking Plaquenil for Rheumatoid Arthritis. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Thanks for the explanation Stoney! I have Sjogren's & severe Neuropathy. I'm new to all of this. I've been looking in to different meds that may help me as I've learned very early in this I must be my biggest advocate or nothing seems to get done w/Dr.s I'm dealing with. If Plaquenil hydroxychloroquine works, it will also help the fatigue. Fatigue is the result of the inflammation. If Plaquenil hydroxychloroquine works, it will also help the fatigue. Plaquenil is a unique drug that helps control/suppress certain autoimmune symptoms. Plaquenil will not work for everyone with autoimmune issues. But there are other drugs like Erythromycin, Azithromycin, Doxycycline, Fluconazole, Malarone, ect. that may work better for your autoimmune condition.