Effect of chloroquine on liver enzymes

Discussion in 'Buy Chloroquine Online' started by a_p, 24-Feb-2020.

  1. RWDesign XenForo Moderator

    Effect of chloroquine on liver enzymes

    Swiss albino mice were administered with different amounts of CQ ranging from human therapeutic equivalent of 360 mg/kg body wt. We observed statistically significant generation of reactive oxygen species, liver toxicity, and oxidative stress. Our observation of alterations in biochemical parameters was strongly supported by real-time PCR measurement of m RNA expression of key biochemical enzymes involved in hepatic toxicity and oxidative stress.

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    The present study was aimed to find out the protective effect of quercetin on hepatotoxicity resulting by commonly used antimalarial drug chloroquine CQ. Swiss albino mice were administered with different amounts of CQ ranging from human therapeutic equivalent of 360 mg/kg body wt. to as high as 2000 mg/kg body wt. The effect of chloroquine CHQ administration on antioxidant enzymes in rat liver and kidney was studied. Male Sprague–Dawley rats were administered 20 mg/kg CHQ once a week for 4 weeks chronic treatment or a single dose at 10 or 20 mg/kg acute treatment. Chloroquine is an antimalarial medication which is used in the treatment as well as prophylaxis of malaria. This medicine is not recommended in patients with the eye disease. Liver function and blood cell count monitoring is necessary while receiving this medicine. Know Chloroquine uses, side effects, dosage, contraindications, benefit, interactions, purpose, drug interactions, precautions.

    We further tested quercetin, an antioxidant flavanoid, against CQ-induced hepatoxicity and found encouraging results as quercetin was able to drastically reduce the oxidative stress and hepatotoxicity resulting at higher dosages of CQ administration. However, the observed hepatotoxicity and accompanying oxidative stress following CQ administration show dose specific pattern with little or apparently no effect at therapeutic dose while having severe effects at higher dosages.

    Effect of chloroquine on liver enzymes

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  6. Despite use for more than 50 years, chloroquine has rarely been linked to serum aminotransferase elevations or to clinically apparent acute liver injury. In patients with acute porphyria and porphyria cutanea tarda, chloroquine can trigger an acute attack with fever and serum aminotransferase elevations, sometimes resulting in jaundice.

    • Chloroquine - LiverTox - NCBI Bookshelf.
    • Chloroquine - Uses, Dosage, Side Effects, Composition..
    • Chloroquine - FDA prescribing information, side effects and uses.

    Our Plaquenil hydroxychloroquine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Jul 30, 2019 Along with its needed effects, chloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine Incidence not known. Anxiety; attempts at killing oneself Can cause overload of liver lysosomes by non-digestible material, increased size and number of liver lysosomes inhibition of several lysosomal enzymes, increased autophagy and fusion disturbances. 12 Administration of chloroquine significantly increases the hepatic and biliary lysosomal

  7. orphan Moderator

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