Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Aralen malaria prophylaxis Plaquenil same as aleve Can you take plaquenil if you are allergic to sulfate Hydroxychloroquine sulfate and sun exposure The mechanism is unknown. Combining telbivudine Tyzeka and hydroxychloroquine may increase the risk of unexplained muscle pain, tenderness, or weakness because both drugs cause such side effects. Hydroxychloroquine suppresses the immune system and should not be combined with drugs that also suppress the immune system or live vaccines. Delayed pressure urticaria is a form of pressure urticaria, which is in turn a form of the condition most of us know as hives. Generally, doctors classify delayed pressure urticaria as a form of "pressure urticaria," which is the reason it's a little difficult to look up on the Internet. Pressure urticaria is condition that causes whelps on the skin. However, delayed pressure urticaria DPU has notoriously been known to be refractory to antihistamines and antihistamines may not control the symptoms completely. 28, 29 Omalizumab, a recombinant DNA monoclonal antibody that binds to IgE, is showing promising results in CIU, with few adverse effects, owing to its ability to decrease mast cell degranulation. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Delayed pressure urticaria hydroxychloroquine Chronic Urticaria Following Practice Guidelines, Pressure Urticaria Triggers, Symptoms, And Treatment Skin. Taking plaquenil and drinking alcoholPlaquenil retinopathy pathogenesisPlaquenil visual side effects Pressure urticaria symptoms may occur immediately at sites of sustained pressure such as over areas of tight clothing or on the buttocks after sitting or more commonly, in delayed pressure urticaria, after a delay of 4–6 hours and last between 12 and 72 hours. Delayed pressure urticaria causes, symptoms, diagnosis.. Pressure Urticaria Treatment & Management Approach.. Pressure Urticaria Background, Pathophysiology, Etiology. Nov 09, 2018 Hydroxychloroquine can cause serious liver or heart problems, especially if you use certain medicines at the same time, including other medicines to treat malaria; an antibiotic or antifungal. Delayed pressure urticaria DPU is characterized by swellings that develop at sites of sustained pressure on the skin several hours after the pressure is removed and can persist for days. DPU is generally difficult to treat successfully. The optimal duration of therapy with cyclosporine is not known. We typically treat patients at a dose required for complete or near-complete control of urticaria for three months and then taper the dose over several months, as tolerated. In the majority of patients, six to nine months of treatment is adequate.