Additionally, another exception occurred while executing the custom error page for the first exception. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Manufacturer of plaquenil Chloroquine method Plaquenil arthritis symptoms This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of Plaquenil hydroxychloroquine, if you use Plaquenil hydroxychloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor right away if. The main outcomes were toxicity as determined by characteristic visual field loss or retinal thinning and photoreceptor damage. They also examined risk factors and prevalence. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs. Peripheral retina was unremarkable OU. Fundus photos, visual field 10-2 were ordered as well as a spectral domain ocular coherence tomography SD-OCT see Figures 1-3. The appearance of disruption of the photoreceptor integrity line, perifoveal thinning, and paracentral scotomas confirmed a high likelihood of toxicity in this patient. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. Plaquenil toxicity 10-2 Despite Plaquenil dosing recommendations, retinal toxicity., My Take on New Ocular Screening Guidelines for Plaquenil. Trametinib hydroxychloroquine The 10-2 HVF with red stimulus was touted as the testing strategy of choice due to its 91% sensitivity for detection of Plaquenil toxicity; however, there is only a 57% specificity. 18 On the converse, the 10-2 white stimulus testing strategy has a lower sensitivity of 78%, but it has a better specificity of 84%. How to Succeed in Plaquenil Screenings. Determine risk for hydroxychloroquine retinal toxicity.. Scotoma analysis of 10-2 visual field testing with a white.. Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. The 10-2 white protocol is recommended as per AAO guidelines, although the red protocol may be more sensitive. Although perimetry is very dependent on patient engagement with the test, it may in some patients be the first modality to detect toxicity, even before mfERG 22, 42, 72 or SD-OCT. SD-OCT Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy.