Chloroquine resistant malaria drug of choice

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  1. pdx User

    Chloroquine resistant malaria drug of choice


    According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance.

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    Artemisinin and other artemether-group drugs have been the main line of defense against drug resistant malaria in many parts of South-East Asia. Artemisinin has been a very potent and effective antimalarial drug, especially when used in combination with other malaria medicines. 3 Combining an artemisinin drug with a partner drug that has a. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided.

    These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine).

    Chloroquine resistant malaria drug of choice

    Drug-resistant malaria is spreading, but experts clash., Chloroquine mechanism of drug action and resistance in.

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  5. CDC has no limits on the use of chloroquine for the prevention of malaria.

    • Medicines for the Prevention of Malaria While Traveling - Chloroquine..
    • Aralen chloroquine Malaria Drug Side Effects & Dosage.
    • Chloroquine - Wikipedia.

    Usual Adult Dose for Malaria. 60 kg or more 1 g chloroquine phosphate 600 mg base orally as an initial dose, followed by 500 mg chloroquine phosphate 300 mg base orally after 6 to 8 hours, then 500 mg chloroquine phosphate 300 mg base orally once a day on the next 2 consecutive days Total dose 2.5 g chloroquine phosphate 1.5 g base in. ANSWER Chloroquine-resistant malaria has been observed in India and so the first line drug of choice should be an artemisinin-derivative in combination with another drug this group of medications are more generally known as "artemisinin-based combination therapies" or ACTs. Drug Resistance In recent years, anti-malarial resistance has been a major concern in treating malaria. For many years, chloroquine CQ was the drug of choice in treating both P. vivax and P. falciparum infections since the drug is cheap and effective.

     
  6. netscout User

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  7. Primera User

    Hydroxychloroquine, the drug that could stop COVID-19. Hydroxychloroquine or Plaquenil It is commonly used to treat various complications as a result of lupus and other connective tissue disorders; that is to say, the set of cells of the organism that has the same function and that constitute the fundamental structure of the different organs of the human body. Uses of Hydroxychloroquine or Plaquenil

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  8. lordfreeman XenForo Moderator

    Retinal Physician - Hydroxychloroquine Maculopathy An Update. Nov 01, 2015 A computerized white-on-white 10-2 visual field test enables good resolution to test for macular sensitivity. The wider visual field tests, such as 24-2, are not sufficiently sensitive to screen the parafoveal region and may miss small scotomas. These tests are therefore not recommended as screening tools. Nevertheless, it is doubtful that the.

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