Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Pct and hydroxychloroquine mechanism Methotrexate plaquenil Hydroxychloroquine visual field test Ocular safety of hydroxychloroquine Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. Less than one person in 5,000 develops the problem. Plaquenil is NOT known to start working that fast. It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. This is the case with everyone I know that takes it. I take Plaquenil for Lupus and it takes 4 to 6 months. For me, it always seems to take 6 months for me to feel the full effect and a marked improvement in my fatigue & joint pain. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. How long does plaquenil take to kick in Plaquenil Uses, Dosage & Side Effects -, Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly? Hydroxychloroquine tablets imagesHydroxychloroquine usmleChloroquine endocytosis inhibitor It may take up to six months before the full benefits of Plaquenil are realized. Dosage The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. Taking Plaquenil for Rheumatoid Arthritis. When does the plaquenil kick in? DailyStrength. Plaquenil - How long to take effect?. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil did help with some of my pains and fatigue. However it does take up to six months for it to fully kick in. As long as you have your eyes checked every 6 months you shouldn't have trouble with the plaquenil. Plaquenil Toxcity takes a long time to build up. Hi everyone, I was just wondering how long it took for Plaquenil to start working for you? I've been on it for about a month now, and it hasn't worked for me yet, but I know that it can take up to 4 months to kick in.