These neuropathies can have different causes and may require different diagnostic techniques & therapeutic strategies. Unlike other autoimmune disorders, in which the neuropathies predominantly cause weakness, the neuropathies in Sjögren’s primarily affect sensation and can cause severe pain. Plaquenil avoid Chloroquine effectiveness Rcophth hydroxychloroquine Symptoms of Neuropathy in Lupus. Symptoms of peripheral neuropathy from lupus can range from mild to serious and mainly affect the hands, feet, legs or arms. They include pain ; burning sensation; numbness; tingling; weakness; inability to sense heat or cold; paralysis ; vision problems; carpal tunnel syndrome; Treatment for Peripheral Neuropathy in Lupus A Disorder Of The Peripheral Nerves That Enable Movement Called Peripheral Motor Neuropathy A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome Jun 25, 2013 plaquenil, peripheral neuropathy, sjogren's syndrome, hydroxychloroquine, methotrexate, muscle I took Plaquenil for Sjogren's Syndrome. It got so I couldn't walk up a curb without help before I switched to oral Methotrexate. Just as most causes of neuropathies and neuropathic pain in Sjögren’s do not come on suddenly, reduction of neuropathic pain can take a while. Initial and predominant neuropathies in Sjögren’s can occur anywhere in the feet, thighs, hands, arms, torso and/or face. Many different symptomatic therapies for neuropathic pain are available. Recognition of unique patterns & causes of neuropathies in Sjögren’s is important in arriving at appropriate therapies. Recognize that neuropathic pain is a chronic disease. Plaquenil peripheral neuropathy Peripheral Neuropathy and Lupus - Kaleidoscope Fighting Lupus, Common and Rare Side Effects for Plaquenil Oral Plaquenil over the counterHydroxychloroquine discontinued side effects Including our patient, there are 10 reported cases of HCQ neuromyotoxicity. Muscle biopsy consistently reveals curvilinear bodies and muscle fiber atrophy with vacuolar changes. Most cases manifest as insidious onset proximal myopathy that may be associated with peripheral neuropathy and cardiac myotoxicity. Hydroxychloroquine neuromyotoxicity.. Hydroxychloroquine - thigh muscle weakness?. Drug‐Induced Peripheral Neuropathy - Vilholm - 2014 - Basic.. Jan 22, 2013 Acquired peripheral neuropathies are caused by systemic disease, trauma from external agents, or infections or autoimmune disorders affecting nerve tissue. Inherited forms of peripheral neuropathy are caused by inborn mistakes in the genetic code or by new genetic mutations. Jun 21, 2016 Introduction Peripheral neuropathy PN is a known but uncommon manifestation of systemic lupus erythematosus SLE. Patients and methods We conducted a retrospective study over 14 years period. Patients diagnosed with SLE revised ACR criteria for SLE diagnosis and presenting PN at any time of the disease course are studied. My understanding is that the rheumatologist thinks that plaquenil is synergistic with mycophenolate and the 2 have a better chance of halting the progression of the neuropathy, and the other current and possible impacts of Sjogren’s better than mycophenolate alone.