Chloroquine mechanism of resistance

Discussion in 'Canada Pharmaceuticals Online' started by spravka, 17-Mar-2020.

  1. timer Well-Known Member

    Chloroquine mechanism of resistance


    However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial rates of chloroquine accumulation are the same.

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    The combination of chloroquine with zinc enhanced chloroquine’s cytotoxicity and induced apoptosis in A2780 cells. Thus chloroquine is a zinc ionophore, a property that may contribute to chloroquine’s anticancer activity. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite.

    These results suggest that a higher rate of chloroquine release explains the lower chloroquine accumulation, and thus the resistance observed in resistant Plasmodium falciparum. Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) Plasmodium falciparum.

    Chloroquine mechanism of resistance

    Malaria Dissecting chloroquine resistance Current Biology, Chloroquine - Wikipedia

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  7. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.

    • CHLOROQUINE PHOSPHATE, USP.
    • Chloroquine C18H26ClN3 - PubChem.
    • Chloroquine mechanism of drug action and resistance in..

    Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. The molecular mechanism of resistance development to chloroquine is still not well understood. It is critical that its mechanism of action be well understood as it is a safe drug, well tolerated in the body and it is further moderately affordable 6. The spread of chloroquine resistance poses a serious challenge to find strategies to treat malaria. an understanding of the molecular mechanisms involved in chloroquine resistance can lead to.

     
  8. Girl_IT Well-Known Member

    Plaquenil is eigenlijk een middel voor de behandeling van malaria en het voorkómen daarvan. Hydroxychloroquine Plaquenil Hydroxychloroquine Side Effects, Dosage, Uses, and More Compare Plaquenil vs Chloroquine -
     
  9. situan Guest

    Plaquenil - FDA prescribing information, side effects and uses Jan 01, 2020 Plaquenil hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration.

    Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  10. creatures User

    Hydroxychloroquine Side-effects, uses, time to work Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD used for rheumatoid arthritis and lupus. Learn how long it takes, risks and side-effects.

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