Hydroxychloroquine-mediated retinopathy

Discussion in 'Canada Pharmaceuticals Online' started by Oleg_G, 28-Feb-2020.

  1. menzar Well-Known Member

    Hydroxychloroquine-mediated retinopathy


    Ophthalmic surveillance was performed on patients in a multicenter clinical trial testing high-dose (1000 mg daily) hydroxychloroquine for advanced non–small cell lung cancer. The US Food & Drug Administration–recommended screening protocol included only visual acuity testing, dilated fundus examination, Amsler grid testing, and color vision testing.

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    In patients with systemic lupus erythematosus SLE, hydroxychloroquine prevents disease flares and damage accrual and facilitates the response to mycophenolate mofetil in those with renal involvement. A study was undertaken to determine whether hydroxychloroquine also exerts a protective effect on survival. Hydroxychloroquine-Induced Myopathy. Article. In this regard, there is already a connection between thiamine deficiency and retinopathy in diabetic patients 30, and diabetic retinopathy can. Asian patients with HCQ retinopathy typically present with a pericentral pattern of retinopathy; that is, such patients show retinal toxicity in the more peripheral retina than white patients.3, 4, 5 However, the extent of retinopathy in Asian patients or how wide the retinopathy can advance remains unclear.

    Out of the 7 patients having exposure of at least 6 months, 2 developed retinal toxicity (at 11 and 17 months of exposure). In patients seen at Stanford, additional sensitive screening procedures were added at the discretion of the retinal physician: high-resolution spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging, Humphrey visual field (HVF) testing, and multifocal electroretinography (mf ERG).

    Hydroxychloroquine-mediated retinopathy

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  7. Retinopathy a case report and literature review Seong Joon Ahn*†, Jooyoung Joung†, Sang Hyup Lee and Byung Ro Lee* Abstract Background Cystoid macular oedema CMO is an uncommon complication associated with hydroxychloroquine HCQ retinopathy threatening central vision. We report a patient with HCQ retinopathy and CMO, for which an

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    Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer - Full Text View. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. A study of about 200 patients with a history of hydroxychloroquine retinopathy, including 36 Asian patients, found that the pericentral pattern occurred in half the Asian patients but only 2% of the white patients. 31 The mechanism for this finding is unclear, but because pericentral retinopathy spares the macula, it can be missed using standard screening methods.

     
  8. 4uda4ka User

    Some side effects may occur that usually do not need medical attention. Hydroxychloroquine Side Effects, Dosage, Uses, and More Plaquenil Hydroxychloroquine - Side Effects, Dosage. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  9. [email protected] Well-Known Member

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  10. braha2005 XenForo Moderator

    Interactions between Chloroquine Oral and qt-prolonging. Taking trazodone with other agents that can affect your heart rhythm may increase your risk of irregular heartbeat, which may be life-threatening. What you should do about this interaction

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