Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine tab Chloroquine mechanism autophagy Allergy signs to hydroxychloroquine Chloroquine is a member of the drug class 4-aminoquinoline. It works against the asexual form of malaria inside the red blood cell. Chloroquine was discovered in 1934 by Hans Andersag. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. Chloroquine hydrochloride Injection 50 mg/ml 40 mg/ml base chloroquine phosphate Tablets 250 mg 150-mg base; 500 mg 300-mg base Indications and dosages Suppressive prophylaxis. Adults 500 mg 300-mg base P. O. on same day once weekly beginning 2 weeks before exposure. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Chloroquine pharmacological class History of antimalarials Medicines for Malaria Venture, Chloroquine hydrochloride - GLOWM Seronegative rheumatoid arthritis and plaquenilIs chloroquine sulfonamides FDA Established Pharmacologic Class EPC Text Phrase PLR regulations require that the following statement is included in the Highlights Indications and Usage heading if a drug is a member of an. FDA Established Pharmacologic Class EPC Text Phrase. Mechanism of action of hydroxychloroquine as an antirheumatic.. Medicines for the Prevention of Malaria While Traveling - Chloroquine.. Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale. Chloroquine prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects. Chloroquine phosphate may cause an upset stomach. Take chloroquine phosphate with food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use chloroquine phosphate exactly as directed. Do not use more or less of it or use it more often than prescribed by your.