However, there are growing problems with drug resistance that are posing a threat to the global fight against malaria. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Chloroquine malarone Define chloroquine Chloroquine is usually taken once per week on the same day each week. Continue taking the medicine regularly during your stay and for at least 8 weeks after you leave the area. If you stop using chloroquine early for any reason, talk to your doctor about other forms of malaria prevention. The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. During the last decade research is gradually repositioning the antimalarial drug chloroquine, and certain related quinoline derivatives, as anticancer agents. Chloroquine and hydroxychloroquine, in particular, have relatively wellcharacterized toxicity profiles due to several decades of use for treatment of malaria. Malaria is common in areas such as Africa, South America, and Southern Asia. Parasites that cause malaria typically enter the body through the bite of a mosquito. Chloroquine target cycle How is malaria treated and prevented? Facts, Chloroquine mechanism of drug action and resistance in. Withdrawal effects of plaquenilChloroquine together with proguanil Of particular interest for human pathology is the report that chloroquine inhibits uncoating of the hepatitis A virus, thus blocking its entire replication cycle. 13 Bishop NE Effects of chloroquine on viral infections an old drug.. New Use for Old Drugs? Prospective Targets of Chloroquines in.. HP ALM Target Release vs Target Cycle. The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium A Comparative Study with Human and Rodent Parasites Michael Delves, 1 David Plouffe, 2 Christian Scheurer, 3, 4 Stephan Meister, 5 Sergio Wittlin, 3, 4 Elizabeth A. Winzeler, 2, 5 Robert E. Sinden, 1 and Didier Leroy 6, * Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.