Acute chloroquine toxicity

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  1. klever2000 Moderator

    Acute chloroquine toxicity


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Chloroquine toxicity and Itching skin 4 causes Chloroquine toxicity and Nausea 4 causes Chloroquine toxicity and Cognitive impairment 3 causes Chloroquine toxicity and Face symptoms 3 causes Chloroquine toxicity and Nerve symptoms 3 causes Chloroquine toxicity and Sensory symptoms 3 causes Chloroquine toxicity and Cardiovascular. The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia. In the 1940's chloroquine and related antimalarials were subjected to extensive pharmacologic and clinical investigations. 1-6 However, the dosage of chloroquine required to treat an acute attack of malaria or for prolonged suppressive therapy was small in comparison to the accumulated chloroquine dose attained in patients in the past decade in the treatment of chronic diseases such as rheumatoid arthritis, discoid lupus, and systemic lupus erythematosus. 7 Recently, numerous reports have.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Acute chloroquine toxicity

    Chloroquine - Wikipedia, Chloroquine Side Effects Common, Severe, Long Term.

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  7. CONCLUSIONS The mortality rate in patients with acute chloroquine poisoning, including those patients sick enough to be referred to a specialty unit such as ours, can be limited to or = 10%. This finding appears to be true even in patients with massive ingestions.

    • Treatment of acute chloroquine poisoning a 5-year experience..
    • Histopathology of Chloroquine Retinal Toxicity JAMA..
    • Hydroxychloroquine-Induced Retinal Toxicity - American..

    Chloroquine CQ is used to prevent and treat malaria and amebiasis, while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome. Children aged under 6 years of age should not be given chloroquine due to the risk of overdose and acute toxicity. The chloroquine dose should be reduced in patients with renal disease, as up to 70% of chloroquine is excreted unchanged in the urine. Chloroquine itself can cause reduced kidney function of up to 10% of patients, especially in those over 60 years of age. Chloroquine is a derivative of 4-aminoquinoline, which is used in the malaria prophylaxis and treatment and the therapy of some connective tissue diseases. Its narrow therapeutic index causes that the medicine is relatively toxic, especially in the case of an overdose or an acute intoxication.

     
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  9. profimarket New Member

    Chloroquine Oral Route Proper Use - Mayo Clinic Proper Use. Drug information provided by IBM Micromedex Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

    Malaria Treatment and Prevention Everyday Health