Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Calcium loss hydroxychloroquin therapy What are chloroquine phosphate tablets used for Chloroquine CQ, a cheap and well-tolerated drug, inhibits the growth of dengue viruses in the laboratory with concentrations achievable in the body. To measure the antiviral efficacy of CQ in dengue, we conducted a study involving 307 adults with suspected dengue. Patients received a 3-day oral dosage of placebo or CQ early in their illness. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Dengue viruses are the most important arthropod-borne viruses in terms of morbidity and mortality in the world. Since there is no dengue vaccine available for human use, we have set out to investigate the use of chloroquine as an antiviral drug against dengue. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine dengue Chloroquine, a FDA-approved Drug, Prevents Zika Virus., Chloroquine Oral Uses, Side Effects, Interactions, Pictures. How u stop plaquenil safelyPrimaquine chloroquine Apr 06, 2015 Dengue virus DENV of the Flaviviridae family is a single positive-stranded RNA virus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. The objective of this study was to investigate the use of chloroquine CLQ as an antiviral drug against dengue virus in monkeys. Antiviral Activity of Chloroquine Against Dengue Virus.. Chloroquine Inhibits Dengue Virus Type 2. Targeting endosomal acidification by chloroquine analogs.. Inhibition of the TNFα receptor was also reported in U937 monocytic cells treated with chloroquine. In the Dengue virus model, chloroquine was found to inhibit interferon-alpha IFNα, IFNβ, IFNγ, TNFα, IL-6 and IL-12 gene expression in U937 cells infected with Dengue-2 virus. 5. Conclusion In the Dengue virus model, chloroquine was found to inhibit interferon-alpha IFNα, IFNβ, IFNγ, TNFα, IL-6 and IL-12 gene expression in U937 cells infected with Dengue-2 virus. 5. Conclusion. Chloroquine has been shown to be capable of inhibiting the in vitro replication of several coronaviruses. Recent publications support the hypothesis. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart.