Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects. Que es plaquenil Chloroquine dose in neonates Plaquenil and elavil Taking plaquenil while on iron supplements The front cover picture shows the binding of the antimalarial drug chloroquine by the lysosomal protein saposin B. Chloroquine is a lysosomotropic drug with toxicity associated with prolonged use. The team was pleasantly surprised to find that saposin B does bind chloroquine. This result was unexpected because saposin B is known to bind lipids—and chloroquine is not a lipid. Atovaquone is a front-line antimalarial drug that functions by competitively inhibiting binding of coenzyme Q10 to the cytochrome bc1 complex. Atovaquone is administered orally, but has low solubility and is poorly absorbed with high variability in bioavailability. While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone. Saposin b binds chloroquine The lysosomal protein saposin B binds chloroquine, Chemists expose side effects of antimalarial drug History of chloroquine resistanceWhat are the parts of chloroquinePlaquenil and apsHydroxychloroquine 200 mg nombre comercial Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Chloroquine - Wikipedia. The antimalarial drug atovaquone binds to saposin B with.. The Lysosomal Protein Saposin B Binds Chloroquine - CORE. Title = "The Lysosomal Protein Saposin B Binds Chloroquine", abstract = "Chloroquine CQ has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. The team identified a protein called saposin B in the lysosome of the human cell and showed that it binds chloroquine. By binding chloroquine, saposin B may reverse the undesirable side effects of chloroquine and alleviate its toxicity, potentially by flushing the drug. Feb 04, 2016 However, the full extent of CQ pharmacology in humans is still unclear. Herein, we demonstrate that the lysosomal protein saposin B sapB, critical for select lipid degradation, binds CQ with implications for both CQ function and toxicity.