Saposin b binds chloroquine

Discussion in 'Canadian Pharmaceuticals Online' started by mlv88, 17-Mar-2020.

  1. smart_bug Well-Known Member

    Saposin b binds chloroquine

    Fadi Bou-Abdallah, Britannia Smith, John Paliakkara; (Second row) Nicholas Flint, Kedwin Ventura; (Back row) Lindsay Johnson, Alaa Farghli, Daniel Coelho Beautiful SUNY Potsdam Campus! The drug chloroquine has long been used to treat malaria, but it is not without side effects.

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    The front cover picture shows the binding of the antimalarial drug chloroquine by the lysosomal protein saposin B. Chloroquine is a lysosomotropic drug with toxicity associated with prolonged use. The team was pleasantly surprised to find that saposin B does bind chloroquine. This result was unexpected because saposin B is known to bind lipids—and chloroquine is not a lipid. Atovaquone is a front-line antimalarial drug that functions by competitively inhibiting binding of coenzyme Q10 to the cytochrome bc1 complex. Atovaquone is administered orally, but has low solubility and is poorly absorbed with high variability in bioavailability.

    While treatments for the disease exist, cures can also take a hefty physical toll. To better understand how chloroquine toxicity occurs, medical researchers set out to investigate what the drug binds to in human cells. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone.

    Saposin b binds chloroquine

    The lysosomal protein saposin B binds chloroquine, Chemists expose side effects of antimalarial drug

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  6. Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.

    • Chloroquine - Wikipedia.
    • The antimalarial drug atovaquone binds to saposin B with..
    • The Lysosomal Protein Saposin B Binds Chloroquine - CORE.

    Title = "The Lysosomal Protein Saposin B Binds Chloroquine", abstract = "Chloroquine CQ has been widely used in the treatment of malaria since the 1950s, though toxicity and resistance is increasingly limiting its use in the clinic. The team identified a protein called saposin B in the lysosome of the human cell and showed that it binds chloroquine. By binding chloroquine, saposin B may reverse the undesirable side effects of chloroquine and alleviate its toxicity, potentially by flushing the drug. Feb 04, 2016 However, the full extent of CQ pharmacology in humans is still unclear. Herein, we demonstrate that the lysosomal protein saposin B sapB, critical for select lipid degradation, binds CQ with implications for both CQ function and toxicity.

  7. brigadir Guest

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Hydroxychloroquine Side Effects, Dosage, Uses, and More Drug spotlight on hydroxychloroquine Lupus Foundation of America Safety of Long term use of Hydroxychloroquine Therapy Further.
  8. artrout Well-Known Member

    Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

    Will you have Fatigue with Plaquenil - eHealthMe
  9. LeGu New Member

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.

    How long does it take for plaquenil to leave your system?