Chloroquine mechanism of action

Discussion in 'Canadian Pharmacy Drugs Online' started by Shevel, 24-Feb-2020.

  1. sergey66 New Member

    Chloroquine mechanism of action


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy. Mechanism of action of chloroquine. Entry into the parasitized RBCs; 1. Accumulation in food vacuole of the parasite- role of pH gradient chloroquine trapping Affects asexual cycle of plasmodium specie. Once administered, it has to enter site of action. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes. Chloroquine inhibits the action of heme polymerase, which causes the buildup of toxic heme in Plasmodium species. 11 It has a long duration of action as the half life is 20-60 days. 10 Patients should be counselled regarding the risk of retinopathy with long term usage or high dosage, muscle weakness, and toxicity in children. 18. Mechanism of action

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Chloroquine mechanism of action

    Chloroquine Mechanism of drug action and resistance in., Chloroquine – howMed

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  5. Chloroquine and hydroxychloroquine are drugs derived from the quinoline molecule. Both are used as antimalarial blood schizonticides, and hydroxychloroquine is also frequently used as an antirheumatic. Their mechanism of action is not entirely understood. However, despite their varying therapeutic dosage and toxicity.

    • Chloroquine and hydroxychloroquine – Knowledge for medical..
    • Chloroquine - DrugBank.
    • On the molecular mechanism of chloroquine's antimalarial action.

    Chloroquine resistance is associated with a decrease in the amount of chloroquine that accumulates in the food vacuole, the site of action for chloroquine. The mechanism for this decreased accumulation is controversial. Some studies have shown that the decrease in drug accumulation is due to an increase in drug efflux. Apr 02, 2019 Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin.

     
  6. Lianidis Moderator

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Proguanil C11H16ClN5 - PubChem Malarone tablets & pediatric tablets Mengenal Avigan dan Chloroquine, Obat yang Dipesan Jokowi.
     
  7. dr_dre XenForo Moderator

    In areas that are highly endemic for Lyme disease, a single prophylactic dose of doxycycline (200 mg for adults or 4.4 mg/kg for children of any age weighing less than 45 kg) may be used to reduce the risk of acquiring Lyme disease after the bite of a high risk tick bite. Will plaquenil kill the encysted form of lyme? Buhner. Doxycycline - Wikipedia User Reviews for Plaquenil to treat Lyme Disease. -
     
  8. ilyazh User

    Hydroxychloroquine Plaquenil Side Effects & Dosage for. The usual adult dose for treating malaria is 800 mg initially, followed by 400 mg 6-8 hours later and then 400 mg at 24 hours and 48 hours. The dose for malaria prevention is 400 mg every week starting 1 or 2 weeks before exposure and for 4 weeks after leaving the high risk area.

    PLAQUENIL hydroxychloroquine sulfate Label
     
  9. woof User

    UpToDate Depending upon comorbidities, prognostic features, and other factors, include sulfasalazine SSZ, hydroxychloroquine HCQ, and other much less frequently used agents. The use of HCQ monotherapy is typically ›

    Plaquenil - Side Effects, Uses, Dosage, Overdose.