Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil toxicity aao Hydroxychloroquine tablets ip 200 mg uses Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. If common side effects do occur, they are usually minor and last only for a short period of time. Please note the rare side effects listed below, specifically retinopathy, which causes damage to the eyes. Side effects associated with Plaquenil are placed in three categories common, less common, and rare. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Common side effects of plaquenil The Risk of Retinal Toxicity with Plaquenil, Hydroxychloroquine Plaquenil Plaquenil for sclerodermaChloroquine phosphate ip 250 mgMethotrexate and plaquenil for rheumatoid arthritisPlaquenil affect immune system Jun 30, 2015 Take Plaquenil exactly as prescribed. Plaquenil comes in tablet form. It is taken once or twice a day, unless it is used for the prevention of malaria, in which case it is taken once a week beginning 1 to 2 weeks prior to traveling to an area where malaria is common. Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These side effects are nothing to be concerned about, but if they start to worsen, then you may seek medical help immediately. Remember that you have been prescribed this medication because your doctor believes that the benefits of Plaquenil are more significant than the side effects.