Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Shortness of breath related to plaquenil Chloroquine glutathione synthase Diseases. It is believed that hydroxychloroquine interferes with communication of cells in the immune system. SIDE is rare. It is recommended that you have an eye exam EFFECTS HOW TO TAKE IT Hydroxychloroquine comes in an oral tablet. Adult dosing ranges from 200mg or 400mg per day 5 mg per kg of actual body weight. In some cases, higher doses Per the prior 2011 AAO guidelines the recommended maximum dose to minimize HCQ retinal toxicity was 6.5 mg /kg based on ideal body weight 2. The advantage of the real body weight formula is that it distributes the risk evenly on a broad range of body habitus. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Hydroxychloroquine dose per kg Hydroxychloroquine Oral Route Proper Use - Mayo Clinic, New Guidelines on Hydroxychloroquine Dosage - Where Are We. How to tell if plaquenil is causing blindness Ideal Body Weight for Calculating Hydroxychloroquine Dosage. The most important risk factor for hydroxychloroquine retinopathy is the daily dose of the drug. If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range /= 6.5 mg/kg/day. Ideal Body Weight for Calculating Hydroxychloroquine Dosage.. Plaquenil Risk Calculators. Plaquenil Dosage Guide -. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Mar 17, 2019 1.5 to 15 years 7 mg/kg orally per day added to first course treatment for JDMS if the patient presented with extensive skin rash and needed steroids in high doses Each dose should be taken with a meal or a glass of milk. What other drugs will affect hydroxychloroquine? This apparently resulted in overdosing of thin patients. Thus, the patient’s real weight is now recommended as the basis for calculating the daily dose per weight in kg. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity.