Indication of chloroquine in pregnancy

Discussion in 'Canadian Pharmacy Online' started by leven, 21-Feb-2020.

  1. bad1 Well-Known Member

    Indication of chloroquine in pregnancy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Pregnancy no contra-indication – Breast-feeding no contra-indication. Remarks – Chloroquine alone without proguanil is used as a prophylactic drug in certain areas where only P. vivax is present. – Resistance of P. vivax to chloroquine exists in Indonesia and Oceania. – Storage below 25 °C - Chloroquine has been reported to reduce the bioavailability of praziquantel. Caution is advised during co-administration. Chloroquine has the potential to increase symptoms of myasthenia gravis and thus diminish effect of neostigmine and pyridostigmine. Concomitant administration of chloroquine with rabies vaccine may affect the antibody response. Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Indication of chloroquine in pregnancy

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  3. The dosage of chloroquine phosphate is often expressed in terms of equivalent chloroquine base. Each 250 mg tablet of chloroquine phosphate is equivalent to 150 mg base and each 500 mg tablet of chloroquine phosphate is equivalent to 300 mg base. In infants and children the dosage is preferably calculated by body weight.

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    Safety of different classes of RA drugs in pregnancy. For some drugs commonly used to treat RA, safety data may be lacking due to the difficulty and ethical considerations associated with testing these drugs in pregnant women. For many drugs used in RA, the risk during pregnancy varies according to the stage of pregnancy. NSAIDs and aspirin Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor. Previously mefloquine was not recommended for the treatment of malaria in pregnant women. The change in recommendations is based on the recent Food and Drug Administration FDA re-categorization of mefloquine from a pregnancy category C drug to category B, based on their review of the published data on mefloquine use during pregnancy.

     
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