Chloroquine metabolism

Discussion in 'Certified Online Canada Pharmacy' started by Debjan_, 21-Feb-2020.

  1. EvgenijCh Moderator

    Chloroquine metabolism


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. The administration of chloroquine or hydroxychloroquine to albino and pigmented hooded rats at a daily dosage of 40 mg/kg produces a rapid rise in tissue concentrations of the drugs during the first month of medication, but comparatively little further rise when the medications are continued for two additional months. Apr 02, 2019 Cimetidine can inhibit the metabolism of chloroquine, increasing its plasma level. Concomitant use of cimetidine should be avoided. Ampicillin. In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. An interval of at least two hours between intake of this agent and chloroquine should be observed.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine metabolism

    Recommendations on Screening for Chloroquine and., Metabolism of chloroquine and hydroxychloroquine in albino.

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    Aug 22, 2005 When chloroquine was added after the initiation of infection, there was a dramatic dose-dependant decrease in the number of virus antigen-positive cells Fig. 2A. As little as 0.1–1 μM chloroquine reduced the infection by 50% and up to 90–94% inhibition was observed with 33–100 μM concentrations Fig. 2B. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Chloroquine has been used for many decades in the prophylaxis and treatment of malaria. It is metabolized in humans through the N-dealkylation pathway, to desethylchloroquine DCQ and bisdesethylchloroquine BDCQ, by cytochrome P450 CYP. However, until recently, no data are available on the metabolic pathway of chloroquine.

     
  6. Turro User

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine - Wikipedia Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center PATIENT FACT SHEET Hydroxychloroquine Plaquenil
     
  7. omlin Well-Known Member

    Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Hilarious Reactions As Report Says Chloroquine Effectively. A Coronavirus Question Chloroquine After Fluoroquinolones. Chloroquine La meilleure solution pour les patients compte.
     
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  9. Zakazchik New Member

    What are the side effects of using hydroxychloroquine. Hydroxychloroquine plaquenil and sulfasalazine azulfidine are used for mild rheumatoid arthritis. they are not as powerful as other dmards, but they usually cause fewer side effects.

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses