I took plaquenil for a while and it helped to reduce the duration/severity of the flairs, but I still had them. Both these drugs can take up to 3 months to begin to work. Plaqenil didn't stop my flare ups, but did ease some of the symptoms. It might also be worth checking what brand you have, as there are many posts on here about adverse reaction to a cheaper brand. Hydroxychloroquine intoxication Plaquenil and shortness of breath Aug 23, 2008 It was the opposite for my husband. Imuran was the only thing that made a difference after suffering for over a year. His imuran started at 75 mg purposely along with 40 mg of prednisone. He had a very long slow taper advice from reading many posts on the forum here due to his steroid dependance and off the prednisone as of early Dec. Find patient medical information for Imuran Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Then he gave me the choice of one tablet of Imuran or 2-3 tablets daily of CellCept. Chose the Imuran but upon educating myself, am wondering if that was the best first choice. Had not heard of Plaquenil. It's all so confusing to a newbie. The prednisone did wonders for the pain and I am still on it so don't know how I'll know if Imuran is working. So it's worth taking some time to think about other possible causes. XBeen taking plaquenil for some 13 years now - seems to reduce the flairs but doesn't stop them. There are many possible triggers for a flare, & as lupus sufferers we are all different. Imuran plaquenil together , Imuran Oral Uses, Side Effects, Interactions, Pictures. Chloroquine injection during pregnancy Learn about drug interactions between azathioprine oral and hydroxychloroquine oral and use the RxList drug interaction checker to check drug combinations. Azathioprine oral and hydroxychloroquine oral Drug.. Treatmenmt for Lupus-Plaquenil and Imuran. Perioperative Management of Medications Used in the.. Thanks for taking the time to reply I'm taking Plaquenil for 4 years the Imuran Azathioprine spwas added during the summer. I do feel better today I did come up with the malar rash which is a sure sign that a flair is on the way but as I said I feel better today and the rash is going down. Maybe the Imuran is working. Drug interactions are reported among people who take Azathioprine and Plaquenil together. This study is created by eHealthMe based on reports of 735 people who take Azathioprine and Plaquenil from Food and Drug Administration FDA, and is updated regularly. eHealthMe has been monitoring drugs since 2008. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients.