I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. It just seems like the fatigue is worse than it has ever been, and it doesn't seem to matter if I go to bed early or take a nap during the day. Woke up and cleaned the kitchen an hour later(my kitchen is a galley kitchen 8 ft maybe.no time) Took a nap. Early on I did get those stomach cramps and diarrhea. All my pain is tolerable and he sees no deformities so he says he doesn't see RA activity. Just because the pain is tolerable doesn't make me like it any better. He did a plaquenil test and sure enough it was low. Plaquenil and unexplained bruising Quinine and chloroquine Can plaquenil cause low platelets Quinacrine and hydroxychloroquine lupus panniculitis When medicines make you tired. If the kind of medication you take is not listed here, check the label for words like “may cause drowsiness.” That can help you know what to expect while you. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. HYDROXYCHLOROQUINE is used to treat rheumatoid arthritis and systemic lupus is also used to treat malaria. The lowest GoodRx price for the most common version of hydroxychloroquine is around $20.41, 88% off the average retail price of $177.73. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I collapse after the kids are put to bed. I don't know if this is just the way RA is, or if it is a side effect of the medicine. Wasn't going to eat luch because I would have to move to do it.husband bought out. Kids came home, helped with homewrok, made dinner..picked up couch(because my blanket and pillow were there) Went to bed at 9. Drowsiness hydroxychloroquine Is extreme fatigue a side effect of Plaquenil?, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Can plaquenil help mononucleosisPlaquenil rash picturesPlaquenil and alcohol interactionPlaquenil como funcionaCan plaquenil cause bruising Hi ellilu, I too am taking Plaquenil and although it has helped with the more severe joint pains and stiffness I am also always fatigued. I was noticing that I'm tired putting a sweater over my head my arms feel tired, showering, driving, getting in and out of my car is a bit tiring. Is extreme fatigue a side effect of Plaquenil - NRAS. Hydroxychloroquine Side Effects - GoodRx. Hydroxychloroquine, Serum - Mayo Clinic Laboratories.. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Ask the poison control center how to induce vomiting in the case of a hydroxychloroquine overdose. Overdose symptoms may include headache, drowsiness, vision changes, slow heart rate, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, seizure convulsions, shallow breathing, or breathing that stops. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments.