While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Hydroxychloroquine and menstrual cycle Hydroxychloroquine nursing implications You can take some anti-malaria medicines safely during pregnancy, but should avoid others. For example Chloroquine and proguanil usually combined can be used in pregnancy, but may not offer enough protection against malaria in many regions, including Africa. You'll also need to take a 5mg supplement of folic acid if you're taking proguanil. Chloroquine or hydroxychloroquine are considered safe to use in all trimesters of pregnancy. Mefloquine is the agent of choice for chloroquine-resistant areas, and evidence suggests it is not associated with an increased risk to the fetus. Is it safe to take chloroquine in pregnancy? There is no evidence that chloroquine is harmful to an unborn baby, although more information about its use in pregnancy ideally needs to be collected. If you are travelling to certain regions you may be advised to take chloroquine. You should not avoid taking chloroquine because you are pregnant. Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Is chloroquine safe during pregnancy Chloroquine - an overview ScienceDirect Topics, Prophylactic use of antimalarials during pregnancy Chloroquine and itching skinChloroquine eye damage So the researchers say it is too soon to declare the drug safe for the small number of pregnant women who might need to take it. The cheapest and mostly widely used anti-malaria drug, called chloroquine, is considered safe during pregnancy. But resistance to that drug has become common worldwide. No birth defect risk seen with malaria drug - Reuters. Bumps - best use of medicine in pregnancy. Chloroquine - Safe In Breastfeeding. Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. There are no controlled data in human pregnancy. CONCLUSION Our findings support preliminary evidence for the safety of HCQ therapy during pregnancy. This treatment probably should be maintained throughout pregnancy in patients with systemic lupus erythematosus. Symptomatic and asymptomatic malaria infections during the first trimester of pregnancy were associated with miscarriage; treatment appeared to be safe. Malaria during pregnancy has adverse effects, including maternal mortality, miscarriage, and low birthweight.