So far I have no more energy than when I first started and has developed neuropathy which I have just found out from Web MD that this neuropathy is one of the side effects of this med! Saying that by stopping this it would take another 6 months to build up the benefit. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion... Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. Chloroquine lysosome ph Hydroxychloroquine retinal toxicity retina replacement Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. If you really need to get off it, I would taper down slowly, very slowly. There is a similar posting on Healthunlocked, "Why oh why did u stop taking plaquenil." You may want to check it out. I do go for intense eye examinations every 6 months to see if there is a difference in my eyesight from my base examine. I do have SJS also. Does anyone know if you have to be weaned off Plaquenil? I've been on it for 15 years, for Lupus? Asked by Lupie523 Updated 27 September 2018. I’m going to see what happens. my life hasn’t been the same since I’ve had to deal with neuropathy. I have up it into my buttocks which causes severe issues sitting. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. Or maybe another doctor if you're not comfortable w/your current one. Running fevers since going off plaquenil PLAQUENIL Side Effects, Reviews by Patients -, Hydroxychloroquine plaquenil withdrawl? - LUPUS UK Afraid to try plaquenilHydroxychloroquine aplastic anemiaPlaquenil tongue He can hear the wheezing and believes the Plaquenil is causing Bronchospasm and the cough. He ran a CT scan to ensure it was not Lymphodema in the chest and it came back fine. The MD told me he was not going to pull me off the Plaquenil, because he did not want the RA sypmtoms to worsen. Plaquenil and Bronchospasm / Cough. DailyStrength. Does anyone know if you have to be weaned off Plaquenil? I.. The Risk of Retinal Toxicity with Plaquenil. As some of you know I started on Plaquenil 6 weeks ago. After two weeks I stopped it because of liver pain, and we found out I had raised liver enzymes. I stayed off it for two weeks until I could contact my rheumatologist who was on holiday My rheumatologist did not think think the Plaquenil w. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. I was diagnosed with lupus SLE almost 9 years ago and take prednisone and plaquenil on a daily basis. I work in a building where there are fluorescent lights. I have been running a fever everyday, anywhere from 100-102 since August when I started work again I have the summers off.