Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil to treat psoriasis Can plaquenil cause insomnia Plaquenil anger Chloroquine works to treat malaria by killing the Plasmodium parasites that cause the infection. This eMedTV segment describes chloroquine's mode of action and provides a link to more detailed information on this medication. An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy. Chloroquine resistance is associated with a decrease in the amount of chloroquine that accumulates in the food vacuole, the site of action for chloroquine. The mechanism for this decreased accumulation is controversial. Some studies have shown that the decrease in drug accumulation is due to an increase in drug efflux. Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria. What is the mode of action of chloroquine PDF Malaria Mode of action of chloroquine and mechanism., Mechanisms of action of hydroxychloroquine and chloroquine. Plaquenil and period changesMalaria treatment drugs chloroquine Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Chloroquine - FDA prescribing information, side effects and uses. Mechanisms of drug action and resistance. Chloroquine and hydroxychloroquine – Knowledge for medical students and.. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Chloroquine is an antimalarial drug. It is also used for other medical conditions. It is not exactly known how its mechanism of action works but it is suspected to inhibit certain enzymes from its interaction with DNA. Chloroquine Clinical Indications. Chloroquine was originally made for the treatment of malaria. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.