Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. Plaquenil and low libido Hydroxychloroquine pregnancy Night swets plaquenil Chloroquine CQ is used to prevent and treat malaria and amebiasis,1 while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome.2 Jun 21, 2012 Hydroxychloroquine Plaquenil is a commonly used medication in the management of various rheumatic diseases. Standard doses used by rheumatologists are 200mg to 400mg per day. Although serious toxicity with hydroxychloroquine is very unusual, the most important is retinal toxicity. Hydroxychloroquine Plaquenil is a very useful drug to treat Rheumatoid Arthritis and Lupus but it can have some significant visual side effects unless properly dosed and monitored. This patient took hydroxychloroquine for rheumatoid arthritis and her vision dropped to 20/300 as a result of the retinal toxicity. In addition to the bull's-eye maculopathy, patients can demonstrate paracentral scotomas on visual field testing and parafoveal outer retinal atrophy on OCT. Plaquenil cataracts toxicity Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy, Hydroxychloroquine Retinopathy, Glucocorticosteroid Induced. Does plaquenil cause fatigueChloroquine sulphate structure FUNDUS AUTO FLUORESCENCE The fundus auto fluorescence confirms Plaquenil toxicity, worse in the left eye than the right eye with an area in the right eye of hyperfluorescence in the macula and the left eye there is an area of hypofluorescence in the macula. The images are slightly compromised by her cataracts. IMPRESSION 1. Plaquenil Toxicity - Mild - Partial Bull's Eye Maculopathy.. What can Hydroxychloroquine Plaquenil do to my eyes?. Multimodal Imaging in Plaquenil Toxicity. Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Bull's-eye maculopathy due to hydroxychloroquine toxicity. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex.