But in those who develop joint pain, fatigue, nerve dysfunction, or fibromyalgia, symptoms can be treated with mild medications. A small percentage of people with Sjogren’s develop more severe inflammation, involving organs such as the kidneys, lungs, intestines, or brain. Dosage of chloroquine injection in adults Does plaquenil affect immune system We have a lot of members here who have never had positive blood work but had SjS confirmed through a biopsy. Plaquenil does not generally help with dryness issues, but is often prescribed to try to slow down the progression of the disease, and does help with inflammation caused by SjS e.g. joint pain and inflammation. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination therapy with other DMARDs for moderate to severe disease. For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. Your doctor may recommend artificial tears to ease the discomfort of dry eye syndrome. For these people, NYU Langone doctors may prescribe more aggressive medications. How does plaquenil work for sjogren's How is plaquenil hydroxychloroquine used to treat lupus?, Taking Plaquenil for Rheumatoid Arthritis Can you get high off hydroxychloroquine 200 mg Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Study Raises Questions about Sjogren's and Plaquenil. Benefits Of Plaquenil - Sjogren's World. Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. Hi - I just started Plaquenil 400 mg a day two week ago and I started feeling less achy and tired a few days ago. Is it possible for it to work quicker in some people? I've heard it can take months, but I must say that I haven't felt like this since I was a kid - not achy or stiff. Has anyone had a similar I read on Wikipedia about the Sjogren's syndrome and I connected the eye dryness with Raynaud's phenomenon. I went to a rheumatologist. I was told to do the anti-nuclear antibodies test, which was negative. Then I was to do some blood-work and check with an eye doctor, regarding the permission to use a drug called Plaquenil.