These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Aralen 250 mg Lysosomal degradation inhibitor chloroquine Chloroquine lysosome sigma Plaquenil. Uses. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of. Side Effects. Precautions. Interactions. Serious side effects and their symptoms can include the following blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or. Inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs loss of hearing lower back or side pain noisy breathing painful or difficult urination red irritated eyes If you notice any other effects, check with your healthcare professional. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Plaquenil eyes side effects The Risk of Retinal Toxicity with Plaquenil, Hydroxychloroquine Side Effects, Dosage, Uses, and More Chloroquine endosomal acidification inhibitor Aug 14, 2017 Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Plaquenil Side Effects on Your Eyes and Vision. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Jun 13, 2019 Plaquenil and your eyes. A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time may harm the retina, causing serious vision loss. People with retinal damage from Plaquenil are not aware at first that they are losing vision. RARE side effects A Change In Vision. Acquired Chromatopsia, A Change In Color Vision. Irritability. Loss Of Muscle Coordination. Low Energy. Mood Changes. Muscle Tremors. Muscle Weakness. Nightmares. Nystagmus, A Condition With Involuntary Eye Movements. Ringing In The Ears. Sensation Of.