Chloroquine protein synthesis

Discussion in 'Chloroquine Without A Doctor Prescription' started by samandar, 07-Mar-2020.

  1. perevod User

    Chloroquine protein synthesis


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    A cell-free protein-synthesizing system has been reconstituted using the S-30 fraction or ribosomes and the S-100 fraction from Plasmodium falciparum. Addition of heme in vitro stimulates cell-free protein synthesis strikingly. Chloroquine inhibits the heme-dependent protein synthesis in the parasite lysate. The drug has also been found to inhibit parasite protein synthesis in situ at. Chloroquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis; it is active against the asexual erythrocytic forms of Plasmodium and Entamoeba species. Gonasun LM, Potts AM. In vitro inhibition of protein synthesis in the retinal pigment epithelium by chloroquine. Invest Ophthalmol 1974; 13 107–115. Ivanina TA, Sakina NL, Lebedeva MN, Borovjagin VL. A study of the mechanisms of chloroquine retinopathy. II. Chloroquine effect on protein synthesis of retina. Ophthalmic Res 1989; 21 272–277.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine protein synthesis

    Synthesis and antimalarial activity of new chloroquine., Antimalarial drugs list, antimalarial drugs side effects.

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  5. A New Synthesis of Chloroquine

    • A New Synthesis of Chloroquine - Journal of the American..
    • Hydroxchloroquine and Chloroquine Toxicity.
    • Chloroquine C18H26ClN3 - PubChem.

    Radioactivity in the RNA and protein samples were determined by liquid scintillation counting Karlsson and Sj~strand 1971. 240 TABLE 1 EFFECT OF CHLOROQUINE ON PROTEIN SYNTHESIS AND RAPID AXONAL TRANSPORT IN RETINAL GANGLION CELLS Rabbits were injected with 500/~g chloroquine into the left eye. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Leupeptin, on the other hand, was the only degradation inhibitor which did not also affect protein synthesis. Chloroquine caused significant cell death at concentrations above 0.2 mmol/l in this protein‐free medium, i.e. in the concentration range needed for maximal inhibition of protein degradation. 6

     
  6. AlёNbI4 Guest

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  7. iosh Well-Known Member

    Generic Plaquenil Hydroxychloroquine - Hi, Im taking Plaquenil for Lupus type symptoms and I know that the brand name product is gluten free but at a month difference, Id love to take the generic. Ive tried to contact Mylan and so has my pharmacist but we cant get a definite answer. Does anyone here have a line into Mylan? Id like.

    Hydroxychloroquine - Wikipedia