I am new to this struggle and my MD is trying to be rather conservative because severe hypothyroidism is complicating my symptoms. But, any info I find is that this medication is sometimes used for RA and can actually make psoriasis worse. Plaquenil monitoring guidelines Plaquenil and mood Hydroxychloroquine plaquenil and surgery Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Interest in hydroxychloroquine treatment of psoriatic arthritis has been revived because of recent series found no exacerbation of psoriatic skin lesions in 50 psoriatic arthropathy patients treated with hydroxychloroquine. A psoriatic arthropathy patient whose skin lesions were markedly exacerbated by hydroxychloroquine is reported. Hydroxychloroquine HCQ Brand Names Plaquenil®, generics. HCQ is a DMARD used to treat inflammatory types of arthritis, such as rheumatoid and psoriatic. ** Originally posted by Jesse Lou ** I have been taking plaquenil since mid-January - 200mg a day the first month, 400mg since then - along with 12.5mg injections of MTX once a week. The MD states it takes about 4 weeks to work (it's now week 3 and I see very little improvement so far). Hydroxychloroquine psoriatic arthritis Psoriasis Causes & Triggers National Psoriasis Foundation, Hydroxychloroquine in psoriatic arthropathy exacerbations. Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquineChloroquine phosphate dosage malaria prophylaxisAralene 2 light semi flush mountHydroxychloroquine vs hydroxychloroquine sulfate In particular, when utilized in psoriatic arthropathy, they have been reported to induce pustular eruption 2, erythroderma 3 and pustular psoriasis 4. We report here a patient with psoriasis and subacute cutaneous lupus erythematosus SCLE who was treated successfully with hydroxychloroquine. Hydroxychloroquine in Psoriasis Is it Really Harmful? HTML.. Hydroxychloroquine HCQ Arthritis Society. Hydroxychloroquine sulfate - Arthritis Foundation. Originally posted by joannapw ** Has anyone had experience with Plaquenil Hydroxychloroquine as treatment for psoriatic arthritis?I am new to this struggle and my MD is trying to be rather conservative because severe hypothyroidism is complicating my symptoms. It is known that antimalarial drugs that are helpful in LE are contraindicated in psoriasis 1. This old concept is supported by the recent study of Wolf et al. 11, who demonstrated that hydroxychloroquine induces hyperproliferation and irregular keratinization in cultured skin of psoriatic patients. I started on plaquenil for Psoriatic Arthritis in 2015. 200mg twice daily. I didn’t feel too bad but a huge bout of stress made my symptoms worse. I then started methotrexate in addition to plaquenil. My rheumatologist suggested once daily Plaquenil and that seemed okay. After a while he said I coujd stop it as he was not sure if it was.