Hydroxychloroquine overdose toxicokinetics and management

Discussion in 'Discount Prescriptions' started by lemmur, 01-Mar-2020.

  1. feelit XenForo Moderator

    Hydroxychloroquine overdose toxicokinetics and management


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydroxychloroquine Plaquenil is an aminoquinoline derivative, closely related to chloroquine, that is used in the treatment of malaria, lupus erythematosus and rheumatoid arthritis. It is available as the sulfate salt Quick treatment of hypotension, gastric decontamination, continuous long-term cardiac monitoring, and treatment of arrhythmias are the cornerstones of hydroxychloroquine overdose management.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Hydroxychloroquine overdose toxicokinetics and management

    Hydroxychloroquine Oral Uses, Side Effects, Interactions., Hydroxychloroquine - Biomedical Publications

  2. Chloroquine sensitive areas
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  4. Hydroxychloroquine – which has a similar toxicity profile – has largely superseded it for the treatment of rheumatoid arthritis. In overdose both chloroquine and hydroxychloroquine cause sodium channel blockade with primarily cardiovascular and central nervous system effects, as well as hypokalemia due to intracellular potassium shifts.

    • Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum.
    • Diazepam for treatment of massive chloroquine intoxication..
    • Treatment of hydroxychloroquine overdose - ScienceDirect.

    Hydroxychloroquine is synthesised by adding a hydroxyl group to an N-ethyl group of chloroquine rendering it 2-4 times less toxic. 1 As hydroxychloroquine and chloroquine share similar structural and pharmacological properties, and there is relatively richer experience with chloroquine toxicity, most of the following discussions are based on studies of Background The management and toxicokinetics of hydroxychloroquine overdose are poorly described. Case Report We report a case of an 18-year-old girl who ingested 20 g of hydroxychloroquine. She developed marked hypokalemia, hypotension, and ventricular tachyarrhythmias but survived with treatment including intubation, adrenaline infusion, high-dose diazepam, and aggressive potassium replacement. Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning 20 g in each case, both of which received advanced cardiac life support and a treatment regimen consisting of sodium bicarbonate, adrenaline and potassium.

     
  5. sjanchuk User

    Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine Oral Route Proper Use - Mayo Clinic Plaquenil - Ask the Expert Plaquenil and Sjögren’s
     
  6. feruza New Member

    Protecting your eyesight when taking Plaquenil Lupus. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs.

    Hydroxychloroquine toxicity - EyeWiki