Chloroquine mechanism autophagy

Discussion in 'Generic Chloroquine Online' started by Mzungu, 29-Feb-2020.

  1. refe-rat Moderator

    Chloroquine mechanism autophagy


    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems.

    Plaquenil for ra Chloroquine and quinine

    Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. The mechanism through which chloroquine is acting on cancer cells has mainly been attributed to the inhibition of autophagy as a consequence of its lysosomotropic properties 13, 24. Consistently, we also observed a strong inhibitory effect of chloroquine on autophagy in the established PDAC cell lines previously used in the cited studies. Since 5-FU induced autophagy in GBC cells, and CQ inhibited autophagy, our findings suggest a possible mechanism that CQ inhibited 5-FU-induced autophagy, which modified the cytotoxicity of 5-FU. The combination therapy of CQ and 5-FU should be considered as an effective strategy for the treatment of gallbladder carcinoma.

    For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor.

    Chloroquine mechanism autophagy

    Chloroquine in Cancer Therapy A Double-Edged Sword of., Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of.

  2. Hydroxychloroquine other uses
  3. Hydroxychloroquine lupus
  4. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.

    • Chloroquine C18H26ClN3 - PubChem.
    • Suppression of autophagy by chloroquine sensitizes 5..
    • Inhibition of autophagy with bafilomycin and chloroquine decreases..

    Up until recently, inhibitory effects of chloroquine on the late stage of autophagy was thought to be the major mechanism underlying cancer cells death from chloroquine. However, recent research provided compelling evidence that autophagy-inhibiting activities of chloroquine are dispensable for its ability to suppress tumor cells growth. There has been long-standing interest in targeting pro-survival autophagy as a combinational cancer therapeutic strategy. Clinical trials are in progress testing chloroquine CQ or its. Among them, only CQ and its derivate hydroxychloroquine HCQ are FDA-approved drugs and are thus currently the principal compounds used in clinical trials aimed to treat tumors through autophagy inhibition. However, the precise mechanism of how CQ blocks autophagy remains to be firmly demonstrated.

     
  5. Damir Moderator

    This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Conditions Plaquenil-related Eye Problems Eugene Eye Care Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil Uses, Dosage & Side Effects -
     
  6. me1-ky XenForo Moderator

    PLAQUENIL® COMPLETE CONTENTS OF THIS LEAFLET BEFORE PRESCRlBlNG PLAQUENIL. Irreversible retinal damage has been observed in some patients who had received long-term or high-dosage 4-aminoquinoline therapy for discoid and systemic lupus erythematosus, or rheumatoid arthritis. Retinopathy has been reported to be dose-related.

    Plaquenil and blood tests? How weird. - Hughes Syndrome
     
  7. SuperYenot New Member

    Chloroquine Uses, Side Effects & Warnings - Follow all directions on your prescription label. Do not take chloroquine in larger or smaller amounts or for longer than recommended. To prevent malaria Start taking the medicine 2 weeks before entering an area where malaria is common. Chloroquine is usually taken once per week on the same day each week.

    Chloroquine - YouTube