B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Plaquenil help hair loss Plaquenil demards Plaquenil bruising Plaquenil retnopathy oct An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. Reactions 1565, p109 - Cutaneous hyperpigmentation 4 case reports Four men developed cutaneous hyperpigmentation during treatment with doxycycline and hydroxychloroquine routes not stated. A 75-year-old man with chronic Q fever received doxycycline 200 mg/day; he had been receiving hydroxychloroquine 400 mg/day for 5 years for rheumatoid arthritis. After 4 months, his. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Cutaneous hyperpigmentation during therapy with hydroxychloroquine Cutaneous Hyperpigmentation During Therapy With Hydroxychlor., Doxycycline/hydroxychloroquine, Reactions Weekly 10.1007. Plaquenil helps joint painWhy do you need eye exams with plaquenilChloroquine sugar cravings Hydroxychloroquine does cross the placenta and is considered Category D in pregnancy see DermNet NZ's pages on Safety of medicines taken during pregnancy and on Lactation and the skin. However, in multiple studies, hydroxychloroquine use has not been associated with congenital disabilities, stillbirth, prematurity, low birth weight, fetal. Hydroxychloroquine DermNet NZ. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Hydroxychloroquine‐induced hyperpigmentation the staining.. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. Background Antimalarials including hydroxychloroquine HCQ have been used in the treatment of systemic lupus erythematosus SLE for more than 50 years. Few cases of hyperpigmentation attributed to HCQ have been reported in the literature from different geographical areas. BACKGROUND Hydroxychloroquine sulfate and other antimalarial drugs have been used successfully as adjunctive therapy for patients with cutaneous lesions of dermatomyositis over the past 20 years. An increased incidence of cutaneous reactions to hydroxychloroquine has been postulated to occur in patients with dermatomyositis.