One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Autoimmune plaquenil Wallace 1989 chloroquine Would chloroquine in a sickle cell patient be harmful Affect of hydroxychloroquine The characteristics of patients which may increase of developing toxicity symptoms while taking Plaquenil include an age of more than 60 years old, having renal or hepatic insufficiency or any existing macular degeneration and retinal disease 1. Aug 29, 2014 The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Symptoms of Plaquenil toxicity are similar to other macular problems and may include Decreased fine vision or difficulty reading. Changes in Color vision. Missing Spots or shadows near the center of the vision. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Signs of plaquenil overdose Treatment of hydroxychloroquine overdose - ScienceDirect, The Risk of Retinal Toxicity with Plaquenil Best time to take plaquenil before or after eatingPlaquenil and etohHydroxychloroquine pmrHydroxychloroquine coat Jivrajka RV, Genead MA, McAnany JJ, Chow CC, Mieler WF. Microperimetric sensitivity in patients on hydroxychloroquine Plaquenil therapy. Eye Lond 2013;27 91044-1052. Martinez-Costa L, Victoria Ibanez M, Murcia-Bello C, et al. Use of microperimetry to evaluate hydroxychloroquine and chloroquine retinal toxicity. Multimodal Imaging in Plaquenil Toxicity. Plaquenil Toxicity Screening - Retina Group of New York. Chloroquine and Hydroxychloroquine • LITFL • Toxicology.. Clinical monitoring for signs and symptoms of cardiomyopathy is advised, including use of appropriate diagnostic tools such as ECG to monitor patients for cardiomyopathy during Plaquenil therapy. Chronic toxicity should be considered when conduction disorders bundle branch block/atrio-ventricular heart block or biventricular hypertrophy are. Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye; Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember.