It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil and glaucoma Plaquenil increased fatigue Plaquenil does it cause bone loss The understanding that one mechanism of action of hydroxychloroquine is the antagonism of TLR7 and TLR9 signaling is also intriguing, given the postulated roles of IFN-α in endothelial dysfunction and abnormal vascular repair. 177 Prospective studies demonstrating a cardioprotective effect of hydroxychloroquine in patients with SLE are needed. The drug still holds its place as a treatment option for some people, particularly in conjunction with methotrexate, or people who have systemic lupus erythematosus. Plaquenil is also an option for those who try and fail biologic drugs, cannot tolerate biologics or fear potential side effects linked to biologic DMARDs. Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. How does hydroxychloroquine work in sle Low Blood Concentration of Hydroxychloroquine in Patients., Taking Plaquenil for Rheumatoid Arthritis Plaquenil ear problemsHydroxychloroquine instructions Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine - Wikipedia. Plaquenil. A medication for Lupus. Lupus Medications and Treatments. Hydroxychloroquine Plaquenil™ What is hydroxychloroquine? Hydroxychloroquine also known as hydroxychloroquine sulfate is an arthritis medicine. that also can be used to prevent malaria. It is available in the United States by prescription only. It is sold under the brand name Plaquenil and it is also sold as a generic medicine. It is. The majority of patients with SLE in the USA have been prescribed hydroxychloroquine HCQ. Given more recent guidelines, the availability of only one strength 200 mg tablets may limit the flexibility and ability to accurately dose patients with lupus. The Lupus Foundation of America undertook a survey to assess the current landscape of HCQ tolerability and adherence. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye.