I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Chloroquine peak plasma concentraion Plaquenil cause dizziness after 2 years It didn't take me long to feel the effects of stopping. I guess I didn't realize how much it was helping me. So far I feel More tired Breathing is more difficult Feels like I am drowning Arms and legs are tingling Numb hands and feet Headache I don't know if this is the result of stopping Plaquenil or just how my Sarcoidosis is presenting. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. Most side effects will go away when your body gets used to the medicine. Tell your doctor if you have these side effects. A lower dose may stop them. Do not lower the dose on your own. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Effects of stopping plaquenil Plaquenil Withdrawal – Life As An Anomaly, Let me tell you what weaning down from Plaquenil is like. Plaquenil and alcohol side effectsCan you drink alcohol with hydroxychloroquineHydroxychloroquine 200 mg discounts Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye; Common and Rare Side Effects for Plaquenil Oral. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Will you have Withdrawal syndrome with Plaquenil - eHealthMe. I can't believe you were told to stop taking plaquenil after only 6 months since it can take up to one YEAR to achieve full benefits! I don't know much about any sort of withdrawal but if I were you I'd start taking it again. I'd also have your thyroid checked. I'm hypothyroid and take levo along with he plaquenil. Has anyone had any side effects from STOPPING plaquenil? Also - does anyone have any great ways to prevent virus and illness, when weak? I seem to get cold after cold after cold this year. I had a diagnosis of seronegative RA in 2017. After two years of plaquenil, my disease is in remission and we have me reduced now to only 100mg per day. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.