Chloroquine dose in tropical splenomegaly

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  1. lui User

    Chloroquine dose in tropical splenomegaly

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    Malaria treatment oral To treat malaria in adults, one dose of oral chloroquine is usually given right away. Then, half the dose is taken six to eight hours later. This is typically followed by half the dose once a day for the next two days. Amebiasis treatment oral To treat amebiasis in adults. Tropical splenomegaly syndrome is an idiopathic disorder prevalent in tropical regions. It is characterized by splenomegaly, elevated levels of serum IgM levels and enlarged liver, or hepatomegaly, caused by abnormal immune responses as a result of repeated malarial infections. Several reports were published over the last century describing patients from tropical areas with massive splenomegaly. After excluding known causes of splenomegaly, tropical splenomegaly syndrome was defined as a separate entity.

    Listing a study does not mean it has been evaluated by the U. Hyper-reactive malarious splenomegaly (HMS) is a known chronic autoimmune complication in areas where malaria is endemic. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. We aim to assess the efficacy of chloroquine after prednisone-induction therapy compared to standard treatment of chloroquine alone in the treatment of adult patients with newly diagnosed hyper-reactive malarial splenomegaly.

    Chloroquine dose in tropical splenomegaly

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures., What Are the Treatments for a Swollen Spleen? Healthfully

  2. Hydroxychloroquine pubchem
  3. Concentrated in erythrocytes, liver, spleen, kidneys, heart, and brain and is strongly bound in melanin-containing cells. Metabolism About 30% of an administered dose is metabolized by the liver to monodesethyl-chloroquine and bidesethylchloroquine.

    • Chloroquine hydrochloride - GLOWM.
    • Tropical Splenomegaly Syndrome Medication Antimalarial Agents.
    • Other Complications – Malaria Site.

    Drome, also known as tropical splenomegaly syndrome, is believed. treatment at a prophylactic dose chloroquine, 300 mg/week. The Artesunate at same daily dose above until parasitemia ≤1% for a maximum of 7 days. Doses given at 0, 12, and 24 hours count as 1 day, which means up to 6 additional days. Proceed with full-dose oral follow-on treatment as above as soon as parasitemia ≤1% and patient able to tolerate oral medications. Antacids and kaolin reduce chloroquine absorption; separate administration by at least 4 hr Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years.

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  6. EcsTasY Well-Known Member

    Chloroquine - an overview ScienceDirect Topics Chloroquine causes a toxic myopathy but also produces a toxic neuropathy. Chloroquine is an antimalarial drug also used for the treatment of severe rheumatoid arthritis, systemic lupus erythematosus, and other dermatological diseases. The clinical features of chloroquine-induced neuropathy are those of symmetrical sensorimotor polyneuropathy.

    Drug-induced myopathies - UpToDate