Hi Dr V, I am at a crossroad of considering to go back on Plaquenil . A year ago I proposed to go off Plaquenil after being on it for 22 years. Hydroxychloroquine-mediated retinopathy Does stopping hydroxychloroquine cold turkey Chloroquine phosphate administration H-chloroquine 200mg PLAQUENIL has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with and without antidiabetic medications. Patients treated with PLAQUENIL should be warned about the risk of hypoglycemia and the associated clinical signs and symptoms. The mean time to peak plasma concentration was 1.83 hours. The mean plasma elimination half-life varied, depending on the post-administration period, as follows 5.9 hours at C max-10 hours, 26.1 hours at 10-48 hours and 299 hours at 48-504 hours. The parent compound and metabolites are widely distributed in the body and elimination is. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. Disease If I had joint or muscle aches, I took care of it by resting, Aleve and ice. At my recent eye exam the doctor mentioned I had reached the plaquenil toxicity level and that my retina cells could die (which do not regenerate! My proposal was based on the fact that I had not had any major inflamation that completely shut me down or keep me from being active. What is the half life of plaquenil Hydroxychloroquine Sulfate Drug Information, Professional, Plaquenil 200mg Film-coated Tablets - Summary of Product. Vortex keratopathy plaquenilChloroquine toxicityDoes plaquenil lower blood pressureI need an eye exam for plaquenilCan plaquenil cause dry mouth I wonder if what you're noticing is really the change in dose. I say this because Plaquenil has a chemical half-life of 30-60 days you can confirm this on wiki or RX info on the drug--so it takes a LONG time to get out of your system.long for you to notice changes in days. Let me tell you what weaning down from Plaquenil is like.. Hydroxychloroquine toxicity - EyeWiki. Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings.. So, I've read the half-life is from 30-60 days. That is one of the reasons I didn't want to take it - that's a long time to stick around. I did read hair loss, photosensitivity, itching area all potential side effects of Plaquenil, so hopefully those will subside soon as the med levels drop. The normal dose of Plaquenil is 1 tablet a day 200mg/day. Some doctors recommend 2 a day 400mg/day but we find that 1 a day suits most people – the dose can always be increased for a flare. One of the attractions of this medication is its long ‘half-life’ – it stays in the system for days & weeks. An analog of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively.