Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Plaquenil price was good rc Diseases treated with plaquenil Is hydroxychloroquine safe With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Scleroderma is a chronic disease that causes abnormal growth of connective tissue. It can affect the joints, skin, and internal organs. It is degenerative and gets worse over time. The disease can be in one area of the body. This is known as localized scleroderma. Or it may affect the whole body. When linear scleroderma occurs on the face and forehead, it is called en coup de sabre. Systemic scleroderma is the most serious form of the disease, can affect the skin, muscles, joints, blood vessels, lungs, kidneys, heart and other organs. There are two major forms of systemic scleroderma limited cutaneous systemic sclerosis formerly. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil scleraderma Cellcept for scleroderma and lupus, Scleroderma Cedars-Sinai Plaquenil endometriosisExpired chloroquine still good Although the medical research community has not come up with any "Proof" that Plaquenil is effective - there are many, many, many people in both the scleroderma & lupus communities who will tell you that Plaquenil was THE drug that helped with symptom relief over the long term with little to no side effects. Just Diagnosed with Crest Syndrome & Prescribed Plaquenil.. Scleroderma. Plaquenil--used To Treat Crest? - Sclero Forums MAIN.. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Systemic sclerosis scleroderma and for what kind of people. The study is created by eHealthMe from 11 Plaquenil users and is updated continuously. eHealthMe has been monitoring drugs since 2008. Scleroderma is a rare condition, and patients with scleroderma need specialized care from a rheumatologist familiar with their condition. The care of patients with scleroderma requires a team approach. Many patients with scleroderma will input from different medical specialties including gastroenterology, pulmonary, cardiology, and others. Hydroxychloroquine Plaquenil is the most common anti-malarial treatment for scleroderma. It is occasionally used in combination with quinacrine, when ineffective on its own. However, quinacrine Atabrine is not available in the U. S. or Canada.