Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Plaquenil stopped my tinitius Chloroquine mechanism of action autophagy Studies in genetically engineered mouse models demonstrate that autophagy inhibition suppresses lung tumor development and progression, especially in Kras mutated tumors. We report safety and efficacy of adding an autophagy inhibitor, hydroxychloroquine HCQ to front-line platinum-based chemotherapy in a phase Ib single arm study in patients. Hydroxychloroquine can be combined with other agents in renal or other solid cancers to augment autophagy inhibition as an anti-cancer mechanism. Abstract. Purpose. Everolimus inhibits the mechanistic target of rapamycin mTOR, activating cytoprotective autophagy. Hydroxychloroquine HCQ inhibits autophagy. Based on Feb 26, 2020 Previous findings supported by the TSCRP suggested that mutated TSC1 and TSC2 suppress autophagy, allowing mutated cells to proliferate. In vitro studies found that administration of autophagy inhibitor hydroxychloroquine in combination with Sirolimus decreased survival of TSC2 deficient cells, and reduced the tumor size in mouse models. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Hydroxychloroquine autophagy inhibitor Hydroxychloroquine sulfate Supplier CAS 747-36-4 Tocris., Autophagy inhibition to augment mTOR inhibition A phase I/II. Plaquenil causing dry mouthPlaquenil nicotinePlaquenil used for raPlaquenil and lichen planus Indeed, preclinical studies have shown that the pharmacological inhibition of autophagy with agents including chloroquine, hydroxychloroquine, metformin, and desmethylclomipramine can enhance the cell-killing effect of cancer therapeutics, and a number of these agents are currently under investigation in clinical trials. However, many of. Chloroquine & Hydroxychloroquine supporting chemo.. Targeting Autophagy for the Treatment of TSC and LAM. Modulation of autophagy with hydroxychloroquine in patients.. Autophagy, a mechanism of recycling intracellular constituents, favors plant growth, especially under nutrient starvation. However, autophagy’s role in regulating postharvest fruit senescence is unclear. Here, effects of the autophagy inhibitor hydroxychloroquine HCQ and activator LiCl on postharvest jujube fruit senescence were investigated. Hydroxychloroquine HCQ is the only clinically-approved autophagy inhibitor, and this systematic review focuses on HCQ use in cancer clinical trials. Preclinical trials have shown that HCQ alone and in combination therapy leads to enhancement of tumor shrinkage. May 30, 2017 3545. Background Colorectal cancer CRC cells can become resistant to chemotherapy and anti-angiogenic therapy through autophagy. The antimalarial agent hydroxychloroquine HCQ is a potent inhibitor of autophagy, and in vivo studies in CRC cell models show significant decrease tumor volume when these autophagy inhibitors were combined with oxaliplatin and bevacizumab.