They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. Chloroquine cancer clinical trial Hydroxychloroquine olecranon bursitis Hydroxychloroquine suppresses the immune system and should not be combined with drugs that also suppress the immune system or live vaccines. QUESTION The term arthritis refers to stiffness in the joints. This dosing would NOT apply to someone already taking plaquenil, because it has a very long ~ 30 days half-life, and it’s already in your system, so you just keep on keep’n on. This is not intended to be medical advice; this is just a reminder to refill whatever Rx for plaquenil you might already have. Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it. Plaquenil tries to quiet or slow down the immune system. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Does plaquenil weaken the immune system Hydroxychloroquine Plaquenil, Having lupus, and being on plaquenil. Does that mean I have a. Plaquenil and vision problemsWhich autoimmune not treat with plaquenil The way it was explained to me is that Plaquenil is not an immunosuppresant, but is used because of its anti-inflammatory effect, so it alone should not lower your ability to fight infections. Logged Plaquenil and lowered immune system - Sjogren's World. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. But you can’t even compare it to the only other things I have to treat lupus—prednisone, where 100 percent of people get side effects, or immunosuppressive drugs, which suppress the immune system, potentially causing infections, low blood counts, and liver toxicity. Evhead17. I'm not a healthcare provider, but I do take Plaquenil and just found out from another user of it that it does suppress the immune system. I didn't know that when I started taking it for Sjogren's in November 2011. In January 2012, I had a horrible cold, stomach flu and then SHINGLES. This action suppresses the normally overactive immune response in lupus patients which may explain one reason Plaquenil works so well for those suffering with lupus. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months.