Had symtoms of malar rash, joint pain especially in hands, fatigue , dry eyes and dry skin . Had a biopsy of skin and confirmed cutaneous lupus. I was put on Plaquenil and for the past 8 years I have been fine with it . Now this year I have been having things pop up that are related to a low immune system. Moa chloroquine malaria Taking hydroxychloroquine for ra Does plaquenil cause leg pain Howdy LadyDi, sorry you are having problems. Plaquenil is what is call an immune modifier. It is not a immune suppressant. Originally it was used to prevent Malaria. Then it was discovered to be effective for the treatment of Lupus. Plaquenil has the least amount of side affects in treating auto immune disorders. Hydroxychloroquine Plaquenil Is An Tl, et al. 2017Hu SC, et al. 2016ConclusionReference I think you need to discuss this issue with your RD. Let him or her know you want some control, but not to make your immune system go permanently insane. I do think that Plaquenil is the mildest drug you can find. I think they all get stronger and more immune-suppressant from there, but I might be wrong! Does anybody have any input concerning taking Plaquenil for long term therapy ? Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack . I tried to only take 100 mg to see if it would make a difference but I started with terrible joint pain and fatigue so I am back on the 200 mg a day. Hydroxychloroquine immune suppressant Lupus Medications and Treatments, Is Hydroxychloroquine Plaquenil an Immunosuppressant. Plaquenil pigmentationPlaquenil hyperpigmentationAralene 2-light flush mount reviewOsteoarthritis medications plaquenilHydroxychloroquine pigmentation Hydroxychloroquine This antimalarial drug has immunomodulatory properties and is used in a variety of autoimmune diseases. It is relatively well tolerated at the commonly used dosages of 200–400 mg/day. Long-term management of patients taking immunosuppressive drugs. Plaquenil and its affect on the immune system DailyStrength. Is Plaquenil an immumo-suppressant?. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days.