Retin-A can do some really great things for your skin (besides clear acne)– there’s no denying that. However, it does require a prescription and some of the side effects are just too intense for many people to tolerate. The good news is, there are a slew of over-the-counter retinol creams that do essentially the same thing as Retin-A, without all the negatives. But before we get to those, let’s take a step back and briefly go over Retin-A and what it does…Retin-A (brand name for the ingredient tretinoin) is a vitamin A derivative that was approved by the FDA over 40 years ago as a prescription acne treatment. In addition to clearing up acne, doctors also noticed that their patients skin also looked brighter, smoother and less wrinkled. That led to Retin-A being used and studied as an anti-aging treatment. 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