Scientists have mapped out a serotonin-driven anxiety circuit that may explain 'anxiety' side effect of antidepressants. More than 100 million people worldwide take selective serotonin reuptake inhibitors (SSRIs), such as Prozac and Zoloft, to treat depression, anxiety and related conditions. More than 100 million people worldwide take selective serotonin reuptake inhibitors (SSRIs), such as Prozac and Zoloft, to treat depression, anxiety and related conditions, but these drugs have a common and mysterious side effect: they can worsen anxiety in the first few weeks of use, which leads many patients to stop treatment. Scientists at the University of North Carolina (UNC) School of Medicine have mapped out a serotonin-driven anxiety circuit that may explain this side effect and lead to treatments to eliminate it. "The hope is that we'll be able to identify a drug that inhibits this circuit and that people could take for just the first few weeks of SSRI use to get over that hump," said senior investigator Thomas L. Kash, Ph D, the John Andrews Distinguished Professor of Alcohol Studies in the UNC School of Medicine's department of pharmacology. "More generally, this finding gives us a deeper understanding of the brain networks that drive anxiety and fear behavior in mammals." The new study, published in , counters the popular view of serotonin as a neurotransmitter that promotes only good feelings. fluconazole 150 mg Zoloft (sertraline) belongs to a class of medications called selective serotonin reuptake inhibitors, or SSRIs. These medications work by increasing the level of serotonin in the brain. Low levels of serotonin in the brain are linked to a depressed mood in addition to cognitive difficulties like poor memory. It's important that you don't expect immediate results when taking Zoloft. 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