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    Tadalafil belongs to a group of medications called phosphodiesterase type 5 inhibitors. It is used to treat erectile dysfunction (male impotence). It helps to achieve and maintain an erection sufficient for sexual activity to occur. It does this by allowing a greater flow of blood into the penis when a man taking the medication is sexually aroused. It works only with sexual stimulation and does not increase sexual desire. Tadalafil is also used to treat symptoms of benign prostatic hyperplasia (BPH) in men with enlarged prostates. It helps to relieve symptoms such as the frequent need to urinate, painful urination, or the sensation of not completely emptying the bladder. xanax 258 Ischemia-reperfusion injury can cause renal damage, and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We investigated the prevention of renal damage using tadalafil after renal ischemia reperfusion (I/R) injury in rats. A total of 21 adult male Wistar albino rats were randomly divided into three groups of seven, including Group 1-control, Group 2-I/R, and Group 3-tadalafil I/R group (I/R-T group) received tadalafil intraperitoneally at 30 minutes before ischemia. Inducible nitric oxide synthase, endothelial nitric oxide synthase, malondialdehyde, and total antioxidant capacity levels were evaluated, and histopathological changes and apoptosis in the groups were examined. Tadalafil decreased malondialdehyde levels in the I/R group and increased the total antioxidant capacity level. Histopathological and immunohistochemical findings revealed that tadalafil decreased renal injury scores and the ratios of injured cells, as measured through apoptotic protease activating factor 1, inducible nitric oxide synthase, and endothelial nitric oxide synthase levels. We suggest that tadalafil has protective effects against I/R-related renal tissue injury.

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    Cialis tablets contain the active ingredient tadalafil, which is a type of medicine called a phosphodiesterase type 5 inhibitor. If you suffer from erectile dysfunction, tadalafil helps you to achieve and maintain an erection by helping more blood get into your penis when you are sexually aroused. An erection is produced via a complex chain of events, involving signals from the nervous system and the release of chemical messengers within the tissues of the penis. One of the messengers released when you're aroused is called cyclic GMP. Cyclic GMP relaxes and widens the blood vessels in the penis, allowing more blood to enter. Cyclic GMP is normally broken down by an enzyme in the body called phosphodiesterase type 5 (PDE5). Tadalafil works by stopping this enzyme from breaking down the cyclic GMP. This allows the blood vessels in the penis to stay dilated for longer, which improves blood flow to the penis and helps produce and maintain an erection. Do a google or yahoo search for "Cialis" and you can find and download the full prescribing information or package circular on line. Your urologist can also answer your questions and if he gives you a sample starter package you will find complete information therein. That includes side effects known when the circular was printed. By clicking Subscribe, I agree to the Terms & Conditions and Privacy Policy and understand that I may opt out of subscriptions at any time.

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