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When bacteriologic testing indicates appropriate susceptibility to the drug, doxycycline may be used to treat these infections caused by Gram-positive bacteria: The World Health Organization Guidelines states that the combination of doxycycline with either artesunate or quinine may be used for the treatment of uncomplicated malaria due to Plasmodium falciparum or following intravenous treatment of severe malaria. Doxycycline kills the symbiotic Wolbachia bacteria in the reproductive tracts of parasitic filarial nematodes, making the nematodes sterile, and thus reducing transmission of diseases such as onchocerciasis and elephantiasis. Doxycycline has been used successfully to treat sexually transmitted, respiratory, and ophthalmic infections. 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This medicine may also be used to treat acne, malaria, and parasitic infection of the intestine (intestinal amoebiasis). This medicine works by preventing the growth and reproduction of bacteria by blocking the protein synthesis. Doxycycline is also used to treat a serious gum infection that damages gums and can destroy the jawbone (periodontitis). Doxycycline may also be used along with other medicines in the treatment of certain conditions as recommended by the doctor. It is used with Amebicides to prevent & treat Amebicide can be used in combination with Doxycycline to treat parasitic infection of the colon (acute intestinal amebiasis), and severe acne problems. This medicine works by the combined action of preventing the bacterial growth (bacteriostatic) and by killing parasites (amebicides). 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