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    The recommended dose of Duloxetine is 40 mg twice daily without regard to meals. After 2-4 weeks of treatment, patients should be re-assessed in order to evaluate the benefit and tolerability of the therapy. Some patients may benefit from starting treatment at a dose of 20 mg twice daily for two weeks before increasing to the recommended dose of 40 mg twice daily. Dose escalation may decrease, though not eliminate, the risk of nausea and dizziness. However, limited data are available to support the efficacy of duloxetine 20 mg twice daily. The efficacy of duloxetine has not been evaluated for longer than 3 months in placebo-controlled studies. The benefit of treatment should be re-assessed at regular intervals. Combining Duloxetine with a pelvic floor muscle training (PFMT) programme may be more effective than either treatment alone. Depressionen sind nicht nur mit affektiven, sondern auch mit krperlichen Symptomen verbunden. Oberstes Therapieziel muss die Remission sein, mahnte Mller. Das sind vor allem Kopf- und Rckenschmerzen, Krmpfe, Nackenverspannungen, Muskelschmerzen, abdominelle Beschwerden und Beklemmungen in der Brust, erluterte Prof. Somatische Beschwerden lavieren hufig die psychischen Symptome wie Antriebsarmut, Interessenverlust, Angst, Gefhl von Schuld und Wertlosigkeit und gedrckte Stimmung (lavierte Depression). Thomas Schlaepfer (Bonn) im Rahmen des APA-Kongresses in Mnchen berichtete, klagen rund 70 Prozent der Patienten beim Arztbesuch nicht ber ihre Stimmungsstrungen, sondern ber Schmerzen. Hans-Jrgen Mller, Direktor der Psychiatrischen Klinik der Universitt Mnchen. Doch gerade in der ambulanten Therapie wrden Antidepressiva aus Angst vor Nebenwirkungen oft nicht hoch genug dosiert. Bei Trizyklika, wie Amitriptylin, msse man bis zu 150 mg/Tag geben, bei modernen Arzneistoffen, wie Venlafaxin, mehr als 100 mg pro Tag, um ausreichende Effekte zu erzielen. Eine weitere Option bietet das duale Wirkprinzip des Antidepressivums Duloxetin (Cymbalta), das zur Gruppe der selektiven Serotonin-Noradrena-lin-Wiederaufnahmehemmer (SSNRI) gehrt. Duloxetin wurde weltweit an mehr als 6 000 erwachsenen Patienten mit Major Depressive Disorder geprft.

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    Duloxetine Oral Route Description and Brand Names - Mayo Clinic, Duloxetine DB00476 - Duloxetine - DrugBank

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