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    Metformin ist ein Arzneistoff aus der Gruppe der Biguanide, der in der Regel bei nicht insulinabhängiger Zuckerkrankheit (Diabetes mellitus Typ 2) und insbesondere bei leichtem Übergewicht (Präadipositas) und krankhaftem Übergewicht (Adipositas) eingesetzt wird. Es ist eines der am längsten und das am häufigsten verabreichte orale Antidiabetikum. Das molekulare Wirkprinzip von Biguaniden ist nach wie vor nicht vollständig geklärt. Klinische Studien zeigen, dass Metformin die Glucose-Neubildung in der Leber hemmt. Experimentelle Studien ergaben, dass Metformin die mitochondriale Glycerin-3-phosphat-Dehydrogenase hemmt. In Folge stehen im Zytosol (siehe auch Glycerin-3-phosphat-Shuttle) weniger Metabolite für die Glucose-Neubildung zur Verfügung, und Laktat fällt vermehrt an. Die seltene Nebenwirkung der Laktatazidose bei Überdosierung kann damit erklärt werden. Metformin – Wikipedia sildenafil for sale Metformin Sandoz 500 mg Tablets - au Metformin medicine to treat type 2 diabetes - NHS. UK
     
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    Cymbalta is the brand name for the drug duloxetine. It belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs work by changing the balance of the chemical messengers serotonin and norepinephrine in your brain. Cymbalta is most often prescribed to treat depression, generalized anxiety disorder, and pain caused by diabetes-related nerve damage in the arms and legs. It’s also prescribed to treat chronic musculoskeletal pain and fibromyalgia, a chronic pain disorder. Many people say their weight changes after they begin taking an SNRI like Cymbalta. However, research doesn’t support that SNRIs are the cause. According to Cymbalta’s prescribing information, people who took the drug actually showed decreased appetite more frequently than people who took a placebo. Additionally, results from a study published in Neuropsychiatric Disease and Treatment also indicated that SNRIs like Cymbalta tended to cause decreased appetite and weight loss. Cymbalta duloxetine hydrochloride capsules - FDA propecia before and after crown TGA eBS - Product and Consumer Medicine Information PI - TGA eBS - Product and Consumer Medicine Information
     
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