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    To better understand its function, consider that an enzyme is a specially folded protein that can speed up a chemical reaction. (For example, the article How Cells Work describes the maltase enzyme.) In the accompanying diagram, you see that maltose is made of two glucose molecules bonded together (1). The maltase enzyme is a protein perfectly shaped to accept a maltose molecule and break the bond (2). A single maltase enzyme can break more than 1,000 maltose bonds per second, and will only accept maltose molecules. PDE5 is an enzyme that accepts c GMP and breaks it down. Pfizer needed a chemical that would gum up PDE5 and keep it from doing its job. The chemical that Pfizer discovered is called sildenafil citrate. It fits right into the PDE5 enzyme and disables it. tadalafil for pulmonary hypertension Ben Valsler This week, Kat Arney takes a long, hard look at the story behind those famous little blue pills. Kat Arney The picturesque town of Sandwich on the Kent coast may seem an unlikely setting for the discovery of what is arguably the world’s most famous drug but it was here, in the labs of pharma company Pfizer, that the story started. Back in the 1980s, a team of medicinal chemists were working on ideas for new drugs to treat angina – a condition that causes narrowing of the blood vessels that supply the heart. Their target was phosphodiesterase 5 (known as PDE5), an enzyme in blood vessel muscles that breaks down cyclic GMP, a small biological molecule. Cyclic GMP normally causes muscles to relax, so the idea was that blocking PDE5 would increase cyclic GMP levels, dilating blood vessels and letting more of the red stuff flow through. The top candidate was a chemical first synthesised in 1989 known as UK92480: a potent and highly selective blocker of PDE5 that could be given in tablet form. Early trials showed that UK92480 did have small effects on blood vessels in healthy volunteers, which was promising.

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    Researchers in Ian Osterloh's lab at Pfizer stopped work on developing sildenafil citrate as a therapy for chest pain in men in 1992 following unpromising results in a Phase I angina study. They noticed, however, that some of the men taking 50- and 75-mg doses in the trial reported an increased tendency to get erections, suggesting a surprise "act two" for sildenafil. "Gradually, a consensus grew that research should shift from angina to the drug's erectile angle, and the rest is, as they say, history," says Daniel J. Viagra was approved by the Food & Drug Administration in 1998 as a therapy for erectile dysfunction (ED), a term for impotence that surfaced in the 1990s. The drug rose swiftly to blockbuster status, achieving sales of $1 billion in its first full year on the market. Physically, Viagra works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5), which normally cleaves cyclic guanosine monophosphate (c GMP), a compound that promotes smooth-muscle relaxation in the corpus cavernosum, thus enhancing blood flow. This enhances the effect of nitric oxide, a chemical released in response to sexual stimulation. Nitric oxide activates guanylate cyclase, an enzyme that boosts levels of c GMP. and Icos, and Bayer Pharmaceutical's Levitra are also PDE5 inhibitors. S, was discovered through a rational drug design programme by the pharmaceutical company Pfizer. It is a potent selective inhibitor of the enzyme phosphodiesterase (PDE-5), which destroys cyclic guanosine monophosphate (c GMP), itself a dilator of blood vessels in the body. Viagra thus allows cyclic GMP to persist and this property has led to its use for the oral treatment of male erectile dysfunction (N. The structures below were modelled using a program called Chem3D from Cambridge Soft, using molecular mechanics (MM2) and quantum mechanics (AM1, PM3) methods.

    Viagra chemical

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  7. Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.

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    Pfizer hit chemical gold 20 years ago when the Food and Drug Administration FDA approved Viagra. But just how much has the “little blue pill. how to purchase viagra in australia Propranolol chemical components viagra tube searching about best pill? A structure, is that medical sildenafil's chemical structure of 100mg canada viagra cialis. Structure, properties, spectra, suppliers and links for Sildenafil citrate, 171599-83-0.

     
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    Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. Sertraline Zoloft NAMI National Alliance on Mental Illness buy acyclovir 800 mg cheap Zoloft Sertraline Hcl Side Effects, Interactions, Warning, Dosage. Zoloft - Common Side Effects, Diagnosis & Legal Claims - Drug Dangers
     
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