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    Skincare will always be of paramount importance for many people, especially females. The skin is the largest organ in the body and varies with different people. This means that individuals differ in how they react to different conditions. Therefore, it is important to know the kind of skin you have before you set out to get products for it. There are so many skin care products in the world with different functions. Hence, there is a need for you to find just exactly what you need and not just what you think would be cool for you. Paying attention to these tips is important because you do not want to use a skin product that would leave your skin worse than it met it simply because it wasn’t compatible with your skin. Know Your Skin People have different kinds of skins and you wouldn’t be surprised that a large population of people do not know what kind of skin they have. If you want to use the best products for your skin, knowing the kind of skin you have would greatly positively influence your decision. When we’re young, our skin stays plump and smooth because it constantly regenerates itself. Luckily, there’s lots you can do to preserve your collagen and even boost its production... Up your vitamin C intake A study published in the American Journal of Nutrition found women over 40 with the highest amount of vitamin C in their diet were less likely to develop wrinkles than those who consumed lower levels. But as we age, collagen production slows – and existing collagen can get damaged due to sun exposure and bad skin habits. “Vitamin C is crucial to the ­formation of collagen - without it amino acids can’t be linked to form the protein,” says dietitian Jo Travers “Good sources are red pepper, dark green leafy veg like broccoli and sprouts, tomatoes, oranges and kiwi fruit.” Skincare that contains vitamin C is also thought to encourage collagen repair (it’s usually listed on the label as L-Ascorbic acid, ascorbyl palmitate or ascorbyl phosphate). Stop smoking “Smoking creates enzymes called matrix metalloproteinases (MMPs) which damage the collagen in your skin, hence the tell-tale sagging which many smokers are betrayed by,” says consultant dermatologist Dr Nick Lowe ( ). Stay sun safe Sun exposure is a prime suspect for hastening collagen loss. “UVA rays penetrate deep into the skin and damage the deep collagen support structures there,” says Dr Lowe. “My advice would be to wear an SPF15 broad spectrum cream (one that protects against UVA and UVB rays) through the year.” 4. Reach for retinol Retinoid creams – only available on prescription – have been proven to help boost collagen production. “Retinoids reduce substances in the skin that break down collagen after sun exposure and also target receptors in the skin which increase the ­production of collagen,” says Dr Maria Gonzalez of the Specialist Skin Clinic ( uk ). Cut back on the sweet stuff According to Dr Patricia Farris, co-author of The Sugar Detox: Lose Weight, Feel Great and Look Years Younger (Bantam £8.99) eating too much sugar can be a beauty disaster. It causes premature ageing of the skin by a process called glycation.

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    The German Institute for Quality and Efficiency in Health Care (IQWi G) investigated whether and what advantages drugs from the drug class of aromatase inhibitors offer compared with other breast cancer treatments or with each other. According to the findings, the data available show advantages over tamoxifen for the early, but not for the late stage of disease: Patients survive longer and recurrences occur later. Overall, the evidence for advanced breast cancer is much poorer. Comparison with other treatments and within the drug class The Federal Joint Committee (G-BA) commissioned IQWi G to perform several comparisons: On the one hand, IQWi G was to compare aromatase inhibitors with other treatment options, in particular the anti-oestrogen tamoxifen. On the other, the Institute was to assess whether the 3 approved drugs from the drug class of aromatase inhibitors (anastrozole, exemestane, letrozole) differ with regard to benefit or harm. Good evidence for early breast cancer As the IQWi G researchers determined, the evidence for early breast cancer is clearly better than for advanced disease: 12 of the overall 19 studies that IQWi G included in the assessment refer to early breast cancer. In July 2015 the results were published of a study that enrolled more than 4000 participants and compared 2 aromatase inhibitors (letrozole, anastrozole). In contrast, the evidence is much poorer for advanced breast cancer. It is also remarkable that none of the studies considered the aspect "health-related quality of life." The assessment is not only based on published studies. Breast Cancer Clinical Trial PALLAS Trial ciprofloxacin what is used for ASCO Aromatase inhibitors alone or with tamoxifen recommended. Use of tamoxifen and aromatase inhibitors in a large population.
     
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